Metal-free regioselective C-H amination for the synthesis of pyrazole-containing 2H-indazoles

被引：19

作者：

Wang, Kai ^{[1
]}

Wei, Tingting ^{[2
]}

Zhang, Yujia ^{[2
]}

Hou, Jiahao ^{[2
]}

Bai, Renren ^{[2
]}

Xie, Yuanyuan ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 08期

关键词：

D O I：

10.1039/d0ob02485f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and practical regioselective approach for the C-H amination of 2H-indazoles under transition-metal-free conditions was developed. A series of substrates were tested showing eminent functional group tolerance and affording the C-N functionalization products in good to excellent yields. Mechanism studies revealed that a radical process was involved in this transformation.

引用

页码：1787 / 1794

页数：8

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