Understanding microRNAs in neurodegeneration

被引：242
|
作者：
Eacker, Stephen M. [1 ,2 ]
Dawson, Ted M. [1 ,2 ,3 ]
Dawson, Valina L. [1 ,2 ,3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Neuroregenerat & Stem Cell Programs, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 12期
关键词：
CEREBRAL AMYLOID ANGIOPATHY; ALPHA-SYNUCLEIN; ALZHEIMER-DISEASE; FRONTOTEMPORAL DEMENTIA; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; LOCUS DUPLICATION; BINDING-SITE; NEURONS; MORPHOGENESIS;
D O I：
10.1038/nrn2726
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.
引用
收藏
页码：837 / 841
页数：5
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