MicroRNAs and regulation of cardiometabolic phenotypes: novel insights into the complexity of genome-wide association studies loci

被引：1
作者：
Civelek, Mete [1 ]
Erdmann, Jeanette [2 ,3 ]
机构：
[1] Univ Virginia, Dept Biomed Engn, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
[2] Univ Lubeck, Univ Heart Ctr Luebeck, Inst Cardiogenet, D-23562 Lubeck, Germany
[3] DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, D-23562 Lubeck, Germany
来源：
CARDIOVASCULAR RESEARCH | 2019年 / 115卷 / 11期
关键词：
EXPRESSION; TRANSCRIPTOME; RISK;
D O I：
10.1093/cvr/cvz120
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1570 / 1571
页数：2
相关论文
共 18 条
  • [1] The role of regulatory variation in complex traits and disease
    Albert, Frank W.
    Kruglyak, Leonid
    [J]. NATURE REVIEWS GENETICS, 2015, 16 (04) : 197 - 212
  • [2] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [3] MicroRNAs in myocardial infarction
    Boon, Reinier A.
    Dimmeler, Stefanie
    [J]. NATURE REVIEWS CARDIOLOGY, 2015, 12 (03) : 135 - 142
  • [4] Identification of cis- and trans- regulatory variation modulating microRNA expression levels in human fibroblasts
    Borel, Christelle
    Deutsch, Samuel
    Letourneau, Audrey
    Migliavacca, Eugenia
    Montgomery, Stephen B.
    Dimas, Antigone S.
    Vejnar, Charles E.
    Attar, Homa
    Gagnebin, Maryline
    Gehrig, Corinne
    Falconnet, Emilie
    Dupre, Yann
    Dermitzakis, Emmanouil T.
    Antonarakis, Stylianos E.
    [J]. GENOME RESEARCH, 2011, 21 (01) : 68 - 73
  • [5] Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits
    Civelek, Mete
    Hagopian, Raffi
    Pan, Calvin
    Che, Nam
    Yang, Wen-pin
    Kayne, Paul S.
    Saleem, Niyas K.
    Cederberg, Henna
    Kuusisto, Johanna
    Gargalovic, Peter S.
    Kirchgessner, Todd G.
    Laakso, Markku
    Lusis, Aldons J.
    [J]. HUMAN MOLECULAR GENETICS, 2013, 22 (15) : 3023 - 3037
  • [6] Mendelian Randomization
    Emdin, Connor A.
    Khera, Amit V.
    Kathiresan, Sekar
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (19): : 1925 - 1926
  • [7] Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
    Franzen, Oscar
    Ermel, Raili
    Cohain, Ariella
    Akers, Nicholas K.
    Di Narzo, Antonio
    Talukdar, Husain A.
    Foroughi-Asl, Hassan
    Giambartolomei, Claudia
    Fullard, John F.
    Sukhavasi, Katyayani
    Koks, Sulev
    Gan, Li-Ming
    Giannarelli, Chiara
    Kovacic, Jason C.
    Betsholtz, Christer
    Losic, Bojan
    Michoel, Tom
    Hao, Ke
    Roussos, Panos
    Skogsberg, Josefin
    Ruusalepp, Arno
    Schadt, Eric E.
    Bjorkegren, Johan L. M.
    [J]. SCIENCE, 2016, 353 (6301) : 827 - 830
  • [8] The Post-GWAS Era: From Association to Function
    Gallagher, Michael D.
    Chen-Plotkin, Alice S.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 102 (05) : 717 - 730
  • [9] Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
    Gamazon, Eric R.
    Segre, Ayellet V.
    van de Bunt, Martijn
    Wen, Xiaoquan
    Xi, Hualin S.
    Hormozdiari, Farhad
    Ongen, Halit
    Konkashbaev, Anuar
    Derks, Eske M.
    Aguet, Francois
    Quan, Jie
    Nicolae, L.
    Eskin, Eleazar
    Kellis, Manolis
    Getz, Gad
    McCarthy, Mark I.
    Dermitzakis, Emmanouil T.
    Cox, Nancy J.
    Ardlie, Kristin G.
    [J]. NATURE GENETICS, 2018, 50 (07) : 956 - +
  • [10] Genetic Architecture of MicroRNA Expression: Implications for the Transcriptome and Complex Traits
    Gamazon, Eric R.
    Ziliak, Dana
    Im, Hae Kyung
    LaCroix, Bonnie
    Park, Danny S.
    Cox, Nancy J.
    Huang, R. Stephanie
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 90 (06) : 1046 - 1063
12