The role of IL-7 in Immunity and Cancer

被引：98
作者：
Lin, Jack [1 ]
Zhu, Ziwen [2 ]
Xiao, Huaping [1 ,3 ]
Wakefield, Mark R. [2 ]
Ding, Vivi A. [1 ]
Bai, Qian [2 ]
Fang, Yujiang [1 ,2 ]
机构：
[1] Des Moines Univ, Coll Osteopath Med, Dept Microbiol Immunol & Pathol, Des Moines, IA 50312 USA
[2] Univ Missouri, Sch Med, Dept Surg, Columbia, MO USA
[3] Xiangnan Univ, Affiliated Hosp, Chenzhou, Peoples R China
来源：
ANTICANCER RESEARCH | 2017年 / 37卷 / 03期
关键词：
IL-7; immunity cancer; review; CYTOTOXIC T-LYMPHOCYTES; RECEPTOR-DEFICIENT MICE; IMMATURE B-CELLS; TCR-GAMMA-LOCUS; BONE-MARROW; INTERLEUKIN-7; RECEPTOR; THYMOCYTE DEVELOPMENT; CYTOKINE RECEPTOR; TRANSGENIC MICE; LINEAGE CELLS;
D O I：
10.21873/anticanres.11405
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.
引用
收藏
页码：963 / 967
页数：5
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