Synthesis and biological evaluation of new 4β-5-Fu-substituted 4′-demethylepipodophyllotoxin derivatives

被引：17

作者：

Zhang, Fu-Min

Yao, Xiao-Jun

Tian, Xuan ^{[1
]}

Tu, Yong-Qiang

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

[3] Xinjiang Prod & Construct Corps, Key Lab Protect & Utilizat Biol Resources Tarim B, Xinjiang, Peoples R China

来源：

MOLECULES | 2006年 / 11卷 / 11期

关键词：

4 '-demethylepipodophyllotoxin; 5-fluorouracil; anticancer activities; partition coefficients;

D O I：

10.3390/11110849

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of new 4 beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 than the reference compound etoposide. In addition, the partition coefficients (P) of all the new and previously synthesized derivatives were determined.

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收藏

页码：849 / 857

页数：9

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