The inhibitory activity of diazinyl-substituted thiourea derivatives on human immunodeficiency virus type 1 reverse transcriptase

被引：22

作者：

Heinisch, G ^{[1
]}

Matuszczak, B ^{[1
]}

Pachler, S ^{[1
]}

Rakowitz, D ^{[1
]}

机构：

[1] UNIV INNSBRUCK, INST PHARMACEUT CHEM, A-6020 INNSBRUCK, AUSTRIA

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1997年 / 8卷 / 05期

关键词：

non-nucleoside HIV reverse transcriptase inhibitor; pyridazine; pyrimidine; pyrazine; diazinyl-substituted thioureas;

D O I：

10.1177/095632029700800507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting from 2-(2-aminoethyl)pyridine, a series of N-daizinyl-N'-[2-(2-pyridyl)ethyl]thioureas was prepared via the (2-pyridyl)ethylisothiocyanate and was screened as non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. Derivatives bearing a 3-pyridazinyl or a 4-pyrimidinyl moiety turned out to be the most potent compounds. However, they exhibited less activity than nevirapine or trovirdine.

引用

页码：443 / 446

页数：4

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