Regulation of IL-4 Expression in Immunity and Diseases

被引：71

作者：

Ho, I-Cheng ^{[1
]}

Miaw, Shi-Chuen ^{[2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

来源：

REGULATION OF CYTOKINE GENE EXPRESSION IN IMMUNITY AND DISEASES | 2016年 / 941卷

关键词：

IL-4; Cytokine; Type 2 immune response; Transcription; Epigenetic; TRANSCRIPTION FACTOR GATA-3; INNATE LYMPHOID-CELLS; LOCUS-CONTROL REGION; CD4(+) T-CELLS; THYMIC STROMAL LYMPHOPOIETIN; GENOME-WIDE ASSOCIATION; TH2 CYTOKINE LOCUS; ALLERGIC AIRWAY INFLAMMATION; INTERLEUKIN-4; RECEPTOR-ALPHA; DNA METHYLTRANSFERASE 3A;

D O I：

10.1007/978-94-024-0921-5_3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past several decades have markedly expanded our understanding of its cellular sources and function. In addition to T cells, IL-4 is produced by innate lymphocytes, such as NTK cells, and myeloid cells, such as basophils and mast cells. It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long non coding RNA. This chapter will review in detail the molecular mechanism regulating the cell type-specific expression of IL-4 in physiological and pathological type 2 immune responses.

引用

页码：31 / 77

页数：47

共 314 条

[101] Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells [J].

Jorritsma, PJ ;

Brogdon, JL ;

Bottomly, K .

JOURNAL OF IMMUNOLOGY, 2003, 170 (05) :2427-2434

[102] Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity [J].

Junttila, Ilkka S. ;

Mizukami, Kiyoshi ;

Dickensheets, Harold ;

Meier-Schellersheim, Martin ;

Yamane, Hidehiro ;

Donnelly, Raymond P. ;

Paul, William E. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (11) :2595-2608

[103] Group 2 innate lymphoid cells and asthma [J].

Kabata, Hiroki ;

Moro, Kazuyo ;

Koyasu, Shigeo ;

Asano, Koichiro .

ALLERGOLOGY INTERNATIONAL, 2015, 64 (03) :227-234

[104] Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue [J].

Kagami, S ;

Nakajima, H ;

Kumano, K ;

Suzuki, K ;

Suto, A ;

Imada, K ;

Davey, HW ;

Saito, Y ;

Takatsu, K ;

Leonard, WJ ;

Iwamoto, I .

BLOOD, 2000, 95 (04) :1370-1377

[105] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells [J].

Kaneko, Takaaki ;

Hosokawa, Hiroyuki ;

Yamashita, Masakatsu ;

Wang, Chrong-Reen ;

Hasegawa, Akihiro ;

Kimura, Motoko Y. ;

Kitajiama, Masayuki ;

Kimura, Fumio ;

Miyazaki, Masaru ;

Nakayama, Toshinori .

MOLECULAR IMMUNOLOGY, 2007, 44 (09) :2249-2256

[106] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements [J].

Kanhere, Aditi ;

Hertweck, Arnulf ;

Bhatia, Urvashi ;

Goekmen, M. Refik ;

Perucha, Esperanza ;

Jackson, Ian ;

Lord, Graham M. ;

Jenner, Richard G. .

NATURE COMMUNICATIONS, 2012, 3

[107]

Kaplan MH, 1999, J IMMUNOL, V163, P6536

[108] Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells [J].

Kaplan, MH ;

Schindler, U ;

Smiley, ST ;

Grusby, MJ .

IMMUNITY, 1996, 4 (03) :313-319

[109] Non-canonical alternatives: What a macrophage is 4 [J].

Karp, Christopher L. ;

Murray, Peter J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (03) :427-431

[110] The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines [J].

Kim, JI ;

Ho, IC ;

Grusby, MJ ;

Glimcher, LH .

IMMUNITY, 1999, 10 (06) :745-751

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