Regulation of IL-4 Expression in Immunity and Diseases

被引：74

作者：

Ho, I-Cheng ^{[1
]}

Miaw, Shi-Chuen ^{[2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

来源：

REGULATION OF CYTOKINE GENE EXPRESSION IN IMMUNITY AND DISEASES | 2016年 / 941卷

关键词：

IL-4; Cytokine; Type 2 immune response; Transcription; Epigenetic; TRANSCRIPTION FACTOR GATA-3; INNATE LYMPHOID-CELLS; LOCUS-CONTROL REGION; CD4(+) T-CELLS; THYMIC STROMAL LYMPHOPOIETIN; GENOME-WIDE ASSOCIATION; TH2 CYTOKINE LOCUS; ALLERGIC AIRWAY INFLAMMATION; INTERLEUKIN-4; RECEPTOR-ALPHA; DNA METHYLTRANSFERASE 3A;

D O I：

10.1007/978-94-024-0921-5_3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past several decades have markedly expanded our understanding of its cellular sources and function. In addition to T cells, IL-4 is produced by innate lymphocytes, such as NTK cells, and myeloid cells, such as basophils and mast cells. It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long non coding RNA. This chapter will review in detail the molecular mechanism regulating the cell type-specific expression of IL-4 in physiological and pathological type 2 immune responses.

引用

页码：31 / 77

页数：47

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