PEA3 family of transcription factors and the regulation of oncogenesis

被引：1
作者：
de Launoit, Yvan
Baert, Jean-Luc
Chotteau-Lelievre, Anne
Monte, Didier
Coutte, Laurent
Mauen, Sebastien
Firlej, Virginie
Degerny, Cindy
Verreman, Kathye
机构：
[1] Univ Lille 1, Univ Lille 2, Inst Pasteur, UMR 8161,Inst Biol Lille, F-59021 Lille, France
[2] Univ Libre Bruxelles, Lab Virol Mol, Fac Med, B-1070 Brussels, Belgium
[3] Univ Paris 11, Lab Biol Anim, Fac Sci, F-91405 Orsay, France
来源：
BULLETIN DU CANCER | 2006年 / 93卷 / 10期
关键词：
metastasis; transcription factor; Ets; PEA3;
D O I：
10.1684/bdc.2006.0036
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Erm, Er81, andPea3 are the three members of the PEA3 group which belong to the Ets transcription factors family, These proteins regulate transcription of multiple target genes, such as those encoding several matrix metalloproteinases (AIMP), which are enzymes degrading the extracellular matrix during cancer metastasis. In fact, PEA3-group genes are often overexpressed in different types of human cancers that also over-express these MMP and display a disseminating phenotype, In experimental models, regulation of PEA3 group member expression has been shown to influence the metastatic process, thus suggesting that these factors play a key role in metastasis.
引用
收藏
页码：985 / 989
页数：5
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