PKB binding proteins: Getting in on the akt

被引：479
作者：
Brazil, DP [1 ]
Park, J [1 ]
Hemmings, BA [1 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
来源：
CELL | 2002年 / 111卷 / 03期
关键词：
D O I：
10.1016/S0092-8674(02)01083-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein kinase B (PKB) has emerged as the focal point for many signal transduction pathways, regulating multiple cellular processes such as glucose metabolism, transcription, apoptosis, cell proliferation, angiogenesis, and cell motility. In addition to acting as a kinase toward many substrates involved in these processes, PKB forms complexes with other proteins that are not substrates, but rather act as modulators of PKB activity and function. In this review, we discuss the implications of these data in understanding the multitude of functions predicted for PKB in cells.
引用
收藏
页码：293 / 303
页数：11
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