Stereoselective Synthesis of Substituted 3a-Hydroxy Diquinanones and 3a-Hydroxy Hydrindanones via Intramolecular Cycloaddition of Nitrile Oxides

被引：2

作者：

Chapelon, Anne-Sophie ^{[1
]}

Giorgi, Michel ^{[2
]}

Ollivier, Cyril ^{[1
]}

Santelli, Maurice ^{[1
]}

机构：

[1] CNRS 6263, Synth Organ Lab, Equipe Chirosci, Marseille, France

[2] Univ Aix Marseille, Fac Sci St Jerome, Marseille, France

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 01期

关键词：

Diquinanones; hydrindanones; intramolecular cyloaddition; nitrile oxides; STEREOCONTROLLED TOTAL-SYNTHESIS; FORMAL TOTAL SYNTHESIS; BETA-HYDROXY KETONES; 1,3-DIPOLAR CYCLOADDITIONS; DIPOLAR CYCLOADDITIONS; NATURAL-PRODUCTS; EPOTHILONE-A; INOC ROUTE; RING; DERIVATIVES;

D O I：

10.1080/00397910902948273

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

trans-1,3-Divinylcyclopentanes bearing a -nitroalkyl chain (C2 or C3) in the 2-position were submitted to an intramolecular nitrile oxide cycloaddition process to give tricyclic isoxazoline precursors of 4-hydroxymethylbicyclo[3.3.0]octan-1-ol-3-ones or 5-hydroxymethyl-9-vinylbicyclo[4.3.0]nonan-1-ol-4-ones.

引用

页码：87 / 103

页数：17

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