Extracellular matrix: an important regulator of cell functions and skeletal muscle development

被引:166
作者
Zhang, Weiya [1 ,2 ]
Liu, Yuan [3 ]
Zhang, Hong [1 ,2 ]
机构
[1] Hebei Agr Univ, Agr Technol Innovat Ctr Mountainous Areas Hebei P, 289 Lingyusi St, Baoding 071001, Hebei, Peoples R China
[2] Hebei Agr Univ, Natl Engn Res Ctr Agr Northern Mt Areas, 289 Lingyusi St, Baoding 071001, Hebei, Peoples R China
[3] Chinese Acad Sci, Inst Zool, Beichen West Rd, Beijing 100101, Peoples R China
关键词
ECM; Skeletal muscle; Cell; Structure; Function; Application;
D O I
10.1186/s13578-021-00579-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which is of great significance to tissue development. ECM in muscle fiber niche consists of three layers: the epimysium, the perimysium, and the endomysium (basal lamina). These three layers of connective tissue structure can not only maintain the morphology of skeletal muscle, but also play an important role in the physiological functions of muscle cells, such as the transmission of mechanical force, the regeneration of muscle fiber, and the formation of neuromuscular junction. In this paper, detailed discussions are made for the structure and key components of ECM in skeletal muscle tissue, the role of ECM in skeletal muscle development, and the application of ECM in biomedical engineering. This review will provide the reader with a comprehensive overview of ECM, as well as a comprehensive understanding of the structure, physiological function, and application of ECM in skeletal muscle tissue.
引用
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页数:13
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