Second Generation APOE2+APOE4- AAV-Mediated Gene Therapy for APOE Homozygotes at Risk for Alzheimer's Disease

被引：0
|
作者：
Montel, Rachel [1 ]
Frenk, Esther [1 ]
Crystal, Ronald G. [1 ]
Stiles, Katie M. [1 ]
机构：
[1] Weill Cornell Med Coll, Genet Med, New York, NY USA
来源：
MOLECULAR THERAPY | 2021年 / 29卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
339
引用
收藏
页码：167 / 168
页数：2
相关论文
共 50 条
  • [1] Second Generation AAV-Mediated Gene Therapy to Mitigate Risk for Alzheimer's Disease in APOE4/4Homozygotes
    Montel, Rachel A.
    Frenk, Esther
    Crystal, Ronald G.
    Stiles, Katie M.
    MOLECULAR THERAPY, 2022, 30 (04) : 395 - 395
  • [2] AAV-Mediated APOE Gene Silencing for Alzheimer's Disease
    Hentschel, Lisa
    Oudshoorn-Dickmann, Maroeska
    Wattimury, Hendrina
    Boggiani, Lorenzo
    Moreno, Fiona
    Tripathi, Shrijana
    Pereira, Ines Lopes
    Nogueira, Ana
    Peris, Sara Gimeno
    Villamil, Javier
    Spronck, Lisa
    Bosma, Bas
    Kusuma, Angga
    Dobrynin, Greg
    Liu, Ying Poi
    MOLECULAR THERAPY, 2022, 30 (04) : 433 - 434
  • [3] AAV-Mediated APOE4 Gene Silencing to Treat Homozygous APOE4-Associated Alzheimer's Disease
    Karan, Kalpita R.
    Kebret, Mara R.
    Hackett, Neil R.
    Crystal, Ronald G.
    MOLECULAR THERAPY, 2024, 32 (04) : 533 - 533
  • [4] Olfactory Dysfunction in ApoE ε4/4 Homozygotes with Alzheimer's Disease
    Oleson, Stephanie
    Murphy, Claire
    JOURNAL OF ALZHEIMERS DISEASE, 2015, 46 (03) : 791 - 803
  • [5] Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
    Huang, Yu-Wen Alvin
    Zhou, Bo
    Nabet, Amber M.
    Wernig, Marius
    Sudhof, Thomas C.
    JOURNAL OF NEUROSCIENCE, 2019, 39 (37): : 7408 - 7427
  • [6] Commentary: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
    Dzianok, Patrycja
    Kublik, Ewa
    FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [7] Suppression of Neurological Deterioration in the APP1.PSEN1/APOE4 Murine Model of Alzheimer's Disease by AAV-Mediated Expression of APOE2 Christchurch
    Gunaydin, Caner
    Lephart, Hailey C.
    Stiles, Katie M.
    Hackett, Neil R.
    Kaminsky, Stephen M.
    Sondhi, Dolan
    Crystal, Ronald G.
    MOLECULAR THERAPY, 2023, 31 (04) : 402 - 403
  • [8] Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
    Huq, Aamira J.
    Fulton-Howard, Brian
    Riaz, Moeen
    Laws, Simon
    Sebra, Robert
    Ryan, Joanne
    Renton, Alan E.
    Goate, Alison M.
    Masters, Colin L.
    Storey, Elsdon
    Shah, Raj C.
    Murray, Anne
    McNeil, John
    Winship, Ingrid
    James, Paul A.
    Lacaze, Paul
    ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2021, 13 (01)
  • [9] Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
    Huq, Aamira J.
    Fransquet, Peter
    Laws, Simon M.
    Ryan, Joanne
    Sebra, Robert
    Masters, Colin L.
    Winship, Ingrid M.
    James, Paul A.
    Lacaze, Paul
    ALZHEIMERS & DEMENTIA, 2019, 15 (12) : 1612 - 1623
  • [10] AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
    Rosenberg, Jonathan B.
    Kaplitt, Michael G.
    De, Bishnu P.
    Chen, Alvin
    Flagiello, Thomas
    Salami, Christiana
    Pey, Eduard
    Zhao, Lingzhi
    Arbona, Rodolfo J. Ricart
    Monette, Sebastien
    Dyke, Jonathan P.
    Balion, Douglas J.
    Kaminsky, Stephen M.
    Sondhi, Dolan
    Petsko, Gregory A.
    Paul, Steven M.
    Crystal, Ronald G.
    HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2018, 29 (01) : 24 - 47
12345