Distribution of heme oxygenase-2 and NADPH-diaphorase in the spinal trigeminal nucleus of the rat

被引：7
作者：
Fan, Wenguo [1 ]
Huang, Fang [1 ,2 ]
Dong, Weiguo [1 ]
Gao, Zhixiong [3 ]
Li, Cuixia [1 ]
Zhu, Xiao [4 ]
Li, Dongpei [4 ]
He, Hongwen [1 ]
机构：
[1] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Oral Anat & Physiol, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Pediat Dent, Guangzhou 510080, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dongshan Div, Guangzhou 510080, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Affiliated Tumor Hosp, Inst Oncol, Guangzhou 510095, Guangdong, Peoples R China
来源：
JOURNAL OF MOLECULAR HISTOLOGY | 2009年 / 40卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Spinal trigeminal nucleus; Heme oxygenase-2; NADPH-diaphorase; Rat; NITRIC-OXIDE SYNTHASE; CARBON-MONOXIDE; NEURONS; CORD; COLOCALIZATION; INVOLVEMENT; MECHANISMS; EXPRESSION; GANGLION; SYSTEM;
D O I：
10.1007/s10735-009-9232-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heme oxygenase (HO)/carbon monoxide (CO) and nitric oxide synthase (NOS)/nitric oxide (NO) systems are involved in sensory information processing. The present study was undertaken to examine the distribution of HO-2 and NOS in the spinal trigeminal nucleus (STN) of the rat, using histochemistry and immunohistochemistry. Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining was found that NADPH-d activity was more prominent in the nucleus caudalis (Vc) and the dorsomedial subdivision of the nucleus oralis (Vo) than in other spinal trigeminal regions. Immunohistochemistry for HO-2 revealed that HO-2 staining neurons distributed extensively, which intensity was higher in the rostral than caudal part of the STN. The colocalization of NADPH-d and HO-2 was mainly confined in the Vc. The expression and distribution of NADPH-d and HO-2 suggest that NO and CO are likely neurotransmitters and might function in the processing orofacial signal in the STN together.
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收藏
页码：209 / 215
页数：7
相关论文
共 37 条
  • [1] Atypical neural messengers
    Barañano, DE
    Ferris, CD
    Snyder, SH
    [J]. TRENDS IN NEUROSCIENCES, 2001, 24 (02) : 99 - 106
  • [2] Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase
    Battish, R
    Cao, GY
    Lynn, RB
    Chakder, S
    Rattan, S
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (01): : G148 - G155
  • [3] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER
    BREDT, DS
    SNYDER, SH
    [J]. NEURON, 1992, 8 (01) : 3 - 11
  • [4] THE ROSTRAL PART OF THE TRIGEMINAL SENSORY COMPLEX IS INVOLVED IN OROFACIAL NOCICEPTION
    DALLEL, R
    RABOISSON, P
    AUROY, P
    WODA, A
    [J]. BRAIN RESEARCH, 1988, 448 (01) : 7 - 19
  • [5] DAWSON TM, 1994, J NEUROSCI, V14, P5147
  • [6] DISTRIBUTION OF NITRIC-OXIDE SYNTHASE-IMMUNOREACTIVE INTERNEURONS IN THE SPINAL TRIGEMINAL NUCLEUS
    DOHRN, CS
    MULLETT, MA
    PRICE, RH
    BEITZ, AJ
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 346 (03) : 449 - 460
  • [7] FALLS WM, 1990, SOMATOSENS MOT RES, V7, P1
  • [8] Expression and colocalization of NADPH-diaphorase and heme oxygenase-2 in trigeminal ganglion and mesencephalic trigeminal nucleus of the rat
    Fan, Wenguo
    Dong, Weiguo
    Leng, Shuilong
    Li, Dongpei
    Cheng, Shaowu
    Li, Cuixia
    Qu, Huaigang
    He, Hongwen
    [J]. JOURNAL OF MOLECULAR HISTOLOGY, 2008, 39 (04) : 427 - 433
  • [9] Involvement of NOS/NO in the development of chronic dental inflammatory pain in rats
    Fan, Wenguo
    Huang, Fang
    Li, Cuixia
    Qu, Huaigang
    Gao, Zhixiong
    Leng, Shuilong
    Li, Dongpei
    He, Hongwen
    [J]. BRAIN RESEARCH REVIEWS, 2009, 59 (02) : 324 - 332
  • [10] GOLGI STUDIES OF SUBSTANTIA GELATINOSA NEURONS IN SPINAL TRIGEMINAL NUCLEUS
    GOBEL, S
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1975, 162 (03) : 397 - 415
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