Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19)

被引：68

作者：

Dupont, Damien ^{[1
,2
]}

Menotti, Jean ^{[1
,3
]}

Turc, Jean ^{[4
]}

Miossec, Charline ^{[1
]}

Wallet, Florent ^{[5
,6
]}

Richard, Jean-Christophe ^{[7
]}

Argaud, Laurent ^{[8
]}

Paulus, Sylvie ^{[9
]}

Wallon, Martine ^{[1
,2
]}

Ader, Florence ^{[10
]}

Persat, Florence ^{[1
,3
]}

机构：

[1] Hosp Civils Lyon, Inst Agents Infect Parasitol & Mycol Med, Hop Croix Rousse, F-69004 Lyon, France

[2] Univ Claude Bernard Lyon 1, Fac Med, Ctr Rech Neurosci Lyon, Physiol Integree Syst Eveil,INSERM U1028,CNRS UMR, Bron, France

[3] Univ Claude Bernard Lyon 1, Inflammat & Immun Resp Epithelium, EA7426 P13, F-69495 Pierre Benite, France

[4] Hosp Civils Lyon, Serv Reanimat Chirurg & Anesthesiol, Hop Edouard Herriot, F-69437 Lyon, France

[5] Hosp Civils Lyon, Serv Reanimat Med, Hop Lyon Sud, F-69495 Pierre Benite, France

[6] Fdn Merieux, Ctr Int Rech Infectiol, Inst Natl Sante & Rech Med U1111, Lab Pathogenes Emergents, F-69007 Lyon, France

[7] Hosp Civils Lyon, Serv Med Intens Reanimat & Surveillance Continue, Hop Croix Rousse, F-69004 Lyon, France

[8] Hosp Civils Lyon, Serv Med Intens Reanimat, Hop Edouard Herriot, F-69437 Lyon, France

[9] Hosp Civils Lyon, Serv Anesthesie Reanimat Pole Est, Hop Louis Pradel, F-69500 Bron, France

[10] Hosp Civils Lyon, Serv Malad Infect & Trop, Hop Croix Rousse, F-69004 Lyon, France

来源：

MEDICAL MYCOLOGY | 2020年 / 59卷 / 01期

关键词：

Aspergillus; pulmonary aspergillosis; COVID-19; intensive care unit; acute respiratory distress syndrome; COVID-19 associated pulmonary aspergillosis (CAPA);

D O I：

10.1093/mmy/myaa078

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed. Lay Abstract Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.

引用

页码：110 / 114

页数：5