Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19)

被引：68

作者：

Dupont, Damien ^{[1
,2
]}

Menotti, Jean ^{[1
,3
]}

Turc, Jean ^{[4
]}

Miossec, Charline ^{[1
]}

Wallet, Florent ^{[5
,6
]}

Richard, Jean-Christophe ^{[7
]}

Argaud, Laurent ^{[8
]}

Paulus, Sylvie ^{[9
]}

Wallon, Martine ^{[1
,2
]}

Ader, Florence ^{[10
]}

Persat, Florence ^{[1
,3
]}

机构：

[1] Hosp Civils Lyon, Inst Agents Infect Parasitol & Mycol Med, Hop Croix Rousse, F-69004 Lyon, France

[2] Univ Claude Bernard Lyon 1, Fac Med, Ctr Rech Neurosci Lyon, Physiol Integree Syst Eveil,INSERM U1028,CNRS UMR, Bron, France

[3] Univ Claude Bernard Lyon 1, Inflammat & Immun Resp Epithelium, EA7426 P13, F-69495 Pierre Benite, France

[4] Hosp Civils Lyon, Serv Reanimat Chirurg & Anesthesiol, Hop Edouard Herriot, F-69437 Lyon, France

[5] Hosp Civils Lyon, Serv Reanimat Med, Hop Lyon Sud, F-69495 Pierre Benite, France

[6] Fdn Merieux, Ctr Int Rech Infectiol, Inst Natl Sante & Rech Med U1111, Lab Pathogenes Emergents, F-69007 Lyon, France

[7] Hosp Civils Lyon, Serv Med Intens Reanimat & Surveillance Continue, Hop Croix Rousse, F-69004 Lyon, France

[8] Hosp Civils Lyon, Serv Med Intens Reanimat, Hop Edouard Herriot, F-69437 Lyon, France

[9] Hosp Civils Lyon, Serv Anesthesie Reanimat Pole Est, Hop Louis Pradel, F-69500 Bron, France

[10] Hosp Civils Lyon, Serv Malad Infect & Trop, Hop Croix Rousse, F-69004 Lyon, France

来源：

MEDICAL MYCOLOGY | 2020年 / 59卷 / 01期

关键词：

Aspergillus; pulmonary aspergillosis; COVID-19; intensive care unit; acute respiratory distress syndrome; COVID-19 associated pulmonary aspergillosis (CAPA);

D O I：

10.1093/mmy/myaa078

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Occurrence of putative invasive pulmonary aspergillosis was screened in 153 consecutive adult intensive care unit (ICU) patients with respiratory samples addressed for mycological diagnosis during a 6-week period at the emergence of coronavirus disease 2019 (COVID-19) pandemic. Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) was observed for 106 patients (69.3%). Nineteen of them (17.9%) with positive Aspergillus results were considered as having putative invasive pulmonary aspergillosis. These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. Standardized surveillance protocols and updated definitions for ICU putative invasive pulmonary aspergillosis are needed. Lay Abstract Adult ICU patients with respiratory samples addressed for mycological diagnosis were screened during the emergence of COVID-19 pandemic. Positive SARS-CoV-2 PCR was observed for 106 patients, nineteen of them (17.9%) having aspergillosis. This underlines the risk of aspergillosis in COVID-19 patients.

引用

页码：110 / 114

页数：5

共 15 条

[1]

Alanio A, 2020, SSRN ELECT J, DOI 10.1101/2020.04.21.20064915

[2] Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project [J].

Bassetti, Matteo ;

Scudeller, Luigia ;

Giacobbe, Daniele R. ;

Lamoth, Frederic ;

Righi, Elda ;

Zuccaro, Valentina ;

Grecchi, Cecilia ;

Rebuffi, Chiara ;

Akova, Murat ;

Alastruey-Izquierdo, Ana ;

Arikan-Akdagli, Sevtap ;

Azoulay, Elie ;

Blot, Stijn I. ;

Cornely, Oliver A. ;

Lass-Floerl, Cornelia ;

Koehler, Philipp ;

Cuenca-Estrella, Manuel ;

de Lange, Dylan W. ;

De Rosa, Francesco G. ;

De Waele, Jan J. ;

Dimopoulos, George ;

Garnacho-Montero, Jose ;

Hoenigl, Martin ;

Kanj, Souha S. ;

Maertens, Johan ;

Martin-Loeches, Ignacio ;

Munoz, Patricia ;

Kullberg, Bart J. ;

Agvald-Ohman, Christina ;

Poulakou, Garyphallia ;

Rello, Jordi ;

Sanguinetti, Maurizio ;

Taccone, Fabio S. ;

Timsit, Jean-Francois ;

Torres, Antoni ;

Vazquez, Jose A. ;

Calandra, Thierry .

MYCOSES, 2019, 62 (04) :310-319

[3] The strategy for the diagnosis of invasive pulmonary aspergillosis should depend on both the underlying condition and the leukocyte count of patients with hematologic malignancies [J].

Bergeron, Anne ;

Porcher, Raphael ;

Sulahian, Annie ;

de Bazelaire, Cedric ;

Chagnon, Karine ;

Raffoux, Emmanuel ;

Vekhoff, Anne ;

Cornet, Muriel ;

Isnard, Francoise ;

Brethon, Benoit ;

Lacroix, Claire ;

Poirot, Jean Louis ;

Bouges, Claire ;

Derouin, Francis ;

Tazi, Abdellatif ;

Ribaud, Patricia .

BLOOD, 2012, 119 (08) :1831-1837

[4] A Clinical Algorithm to Diagnose Invasive Pulmonary Aspergillosis in Critically Ill Patients [J].

Blot, Stijn I. ;

Taccone, Fabio Silvio ;

Van den Abeele, Anne-Marie ;

Bulpa, Pierre ;

Meersseman, Wouter ;

Brusselaers, Nele ;

Dimopoulos, George ;

Paiva, Jose A. ;

Misset, Benoit ;

Rello, Jordi ;

Vandewoude, Koenraad ;

Vogelaers, Dirk .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :56-64

[5] Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium [J].

Donnelly, J. Peter ;

Chen, Sharon C. ;

Kauffman, Carol A. ;

Steinbach, William J. ;

Baddley, John W. ;

Verweij, Paul E. ;

Clancy, Cornelius J. ;

Wingard, John R. ;

Lockhart, Shawn R. ;

Groll, Andreas H. ;

Sorrell, Tania C. ;

Bassetti, Matteo ;

Akan, Hamdi ;

Alexander, Barbara D. ;

Andes, David ;

Azoulay, Elie ;

Bialek, Ralf ;

Bradsher, Robert W., Jr. ;

Bretagne, Stephane ;

Calandra, Thierry ;

Caliendo, Angela M. ;

Castagnola, Elio ;

Cruciani, Mario ;

Cuenca-Estrella, Manuel ;

Decker, Catherine F. ;

Desai, Sujal R. ;

Fisher, Brian ;

Harrison, Thomas ;

Heussel, Claus Peter ;

Jensen, Henrik E. ;

Kibbler, Christopher C. ;

Kontoyiannis, Dimitrios P. ;

Kullberg, Bart-Jan ;

Lagrou, Katrien ;

Lamoth, Frederic ;

Lehrnbecher, Thomas ;

Loeffler, Jurgen ;

Lortholary, Olivier ;

Maertens, Johan ;

Marchetti, Oscar ;

Marr, Kieren A. ;

Masur, Henry ;

Meis, Jacques F. ;

Morrisey, C. Orla ;

Nucci, Marcio ;

Ostrosky-Zeichner, Luis ;

Pagano, Livio ;

Patterson, Thomas F. ;

Perfect, John R. ;

Racil, Zdenek .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1367-1376

[6] Invasive fungal diseases during COVID-19: We should be prepared [J].

Gangneux, J. -P. ;

Bougnoux, M. -E. ;

Dannaoui, E. ;

Cornet, M. ;

Zahar, J. R. .

JOURNAL DE MYCOLOGIE MEDICALE, 2020, 30 (02)

[7] COVID-19 associated pulmonary aspergillosis [J].

Koehler, Philipp ;

Cornely, Oliver A. ;

Boettiger, Bernd W. ;

Dusse, Fabian ;

Eichenauer, Dennis A. ;

Fuchs, Frieder ;

Hallek, Michael ;

Jung, Norma ;

Klein, Florian ;

Persigehl, Thorsten ;

Rybniker, Jan ;

Kochanek, Matthias ;

Boell, Boris ;

Shimabukuro-Vornhagen, Alexander .

MYCOSES, 2020, 63 (06) :528-534

[8] Acute Respiratory Distress Syndrome The Berlin Definition [J].

Ranieri, V. Marco ;

Rubenfeld, Gordon D. ;

Thompson, B. Taylor ;

Ferguson, Niall D. ;

Caldwell, Ellen ;

Fan, Eddy ;

Camporota, Luigi ;

Slutsky, Arthur S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (23) :2526-2533

[9] Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study [J].

Schauwvlieghe, Alexander F. A. D. ;

Rijnders, Bart J. A. ;

Philips, Nele ;

Verwijs, Rosanne ;

Vanderbeke, Lore ;

Van Tienen, Carla ;

Lagrou, Katrien ;

Verweij, Paul E. ;

Van de Veerdonk, Frank L. ;

Gommers, Diederik ;

Spronk, Peter ;

Bergmans, Dennis C. J. J. ;

Hoedemaekers, Astrid ;

Andrinopoulou, Eleni-Rosalina ;

van den Berg, Charlotte H. S. B. ;

Juffermans, Nicole P. ;

Hodiamont, Casper J. ;

Vonk, Alieke G. ;

Depuydt, Pieter ;

Boelens, Jerina ;

wauters, Joost .

LANCET RESPIRATORY MEDICINE, 2018, 6 (10) :782-792

[10] COVID-19-associated Pulmonary Aspergillosis [J].

van Arkel, Andreas L. E. ;

Rijpstra, Tom A. ;

Belderbos, Huub N. A. ;

Van Wijngaarden, Peter ;

Verweij, Paul E. ;

Bentvelsen, Robbert G. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (01) :132-135

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