Photodynamic Therapy of Sarcoma M-1 in Rats with Photosensitizer Photoran E6

被引：5

作者：

Abramova, O. B. ^{[1
]}

Yuzhakov, V. V. ^{[1
]}

Kaplan, M. A. ^{[1
]}

Drozhzhina, V. V. ^{[1
]}

Beregovskaya, E. A. ^{[1
]}

Churikova, T. P. ^{[1
]}

Sevan'kaeva, L. E. ^{[1
]}

Fomina, N. K. ^{[1
]}

Tsyganova, M. G. ^{[1
]}

Ivanov, S. A. ^{[1
]}

Kaprin, A. D. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Affiliated Branch Natl Med Res Radiol Ctr, AF Tsyb Med Radiol Res Ctr, Obninsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 04期

关键词：

photodynamic therapy; Photoran E6; sarcoma M-1; immunohistochemistry; mutant p53 protein;

D O I：

10.1007/s10517-021-05092-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effectiveness of photodynamic therapy with the photosensitizer Photoran E6 on the model of rat sarcoma M-1 positive for mutant p53 gene. Experiments showed that Photoran E6 exhibits high antitumor activity in photodynamic therapy of solid tumor of the connective tissue. Photodynamic therapy carried out during the optimal period after injections of Photoran E6 with the determined parameters of laser exposure allows achieving the maximum inhibitory effect on sarcoma M-1: 100% cured animals. Immunohistochemical study revealed no live tumor cells with expression of the mutant p53 protein in areas of photodynamic exposure.

引用

页码：479 / 484

页数：6

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