An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids

被引：24

作者：

Abbas, S ^{[1
]}

Hayes, CJ ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

antisense; palladium coupling; vinyl bromide; oligonucleotide; modified backbone;

D O I：

10.1016/S0040-4039(00)00653-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a range of 5'-deoxy-5'-methylidene phosphonate-containing thymidine dimers has been achieved using a palladium-catalysed cross coupling reaction as a key step. The optimised reaction conditions comprising of palladium acetate, 1,1'-bis(diphenylphosphino)ferrocene and propylene oxide in THF were found to couple a range of N-phosphonates and vinyl bromide 3 in fair to excellent yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：4513 / 4517

页数：5

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