Unexplained neurologic symptoms: An fMRI study of sensory conversion disorder

被引：72

作者：

Ghaffar, Omar

Staines, W. Richard

Feinstein, Anthony

机构：

[1] Univ Toronto, Dept Psychiat, Sunnybrook Hlth Sci Ctr, Div Neuropsychiat, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Dept Neurol, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[3] Univ Waterloo, Canada Res Chair Sensorimotor Control, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada

来源：

NEUROLOGY | 2006年 / 67卷 / 11期

关键词：

D O I：

10.1212/01.wnl.0000247275.68402.fc

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated three subjects with unexplained sensory loss meeting criteria for conversion disorder using brain fMRI during unilateral and bilateral vibrotactile stimulation. In each subject, stimulation of the affected limb did not produce activation of the contralateral primary somatosensory (S1) region, whereas bilateral limb stimulation did. These findings implicate selective alterations in primary sensorimotor cortex activity in conversion disorder, and may also reconcile the discordant results of previous studies.

引用

收藏

页码：2036 / 2038

页数：3

相关论文

共 10 条

[1] Abnormal brain activation during movement observation in patients with conversion paralysis [J].

Burgmer, M ;

Konrad, C ;

Jansen, A ;

Kugel, H ;

Sommer, J ;

Heindel, W ;

Ringelstein, EB ;

Heuft, G ;

Knecht, S .

NEUROIMAGE, 2006, 29 (04) :1336-1343

[2] New devices to deliver somatosensory stimuli during functional MRI [J].

Graham, SJ ;

Staines, WR ;

Nelson, A ;

Plewes, DB ;

McIlroy, WE .

MAGNETIC RESONANCE IN MEDICINE, 2001, 46 (03) :436-442

[3] The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology [J].

Kringelbach, ML ;

Rolls, ET .

PROGRESS IN NEUROBIOLOGY, 2004, 72 (05) :341-372

[4] Altered central somatosensory processing in chronic pain patients with "hysterical" anesthesia [J].

Mailis-Gagnon, A ;

Giannoylis, I ;

Downar, J ;

Kwan, CL ;

Mikulis, DJ ;

Crawley, AP ;

Nicholson, K ;

Davis, KD .

NEUROLOGY, 2003, 60 (09) :1501-1507

[5]

MARSHALL JC, 1997, COGNITION, V64, P1

[6] Illusory persistence of touch after right parietal damage: neural correlates of tactile awareness [J].

Schwartz, S ;

Assal, F ;

Valenza, N ;

Seghier, ML ;

Vuilleumier, P .

BRAIN, 2005, 128 :277-290

[7] Discrete neurophysiological correlates in prefrontal cortex during hysterical and feigned disorder of movement [J].

Spence, SA ;

Crimlisk, HL ;

Cope, H ;

Ron, MA ;

Grasby, PM .

LANCET, 2000, 355 (9211) :1243-1244

[8] Task-relevant modulation of contralateral and ipsilateral primary somatosensory cortex and the role of a prefrontal-cortical sensory gating system [J].

Staines, WR ;

Graham, SJ ;

Black, SE ;

McIlroy, WE .

NEUROIMAGE, 2002, 15 (01) :190-199

[9] ALTERED CEREBRAL BLOOD PLOW DURING HYSTERICAL PARESTHESIA [J].

TIIHONEN, J ;

KUIKKA, J ;

VIINAMAKI, H ;

LEHTONEN, J ;

PARTANEN, J .

BIOLOGICAL PSYCHIATRY, 1995, 37 (02) :134-135

[10] Functional neuroanatomical correlates of hysterical sensorimotor loss [J].

Vuilleumier, P ;

Chicherio, C ;

Assal, F ;

Schwartz, S ;

Slosman, D ;

Landis, T .

BRAIN, 2001, 124 :1077-1090