An "in silico" Bench to Bedside Approach to Investigating Sepsis Biomarkers

被引：0

作者：

O'Mahony, Grace ^{[1
]}

Hawthorne, Christopher ^{[1
]}

McQuaid, Karl ^{[1
]}

Lopez-Campos, Guillermo H. ^{[1
]}

机构：

[1] Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland

来源：

DIGITAL PERSONALIZED HEALTH AND MEDICINE | 2020年 / 270卷

关键词：

Biomarkers; Bioinformatics; Sepsis; Natural language processing;

D O I：

10.3233/SHTI200359

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Sepsis results in various patient complications and is due to a heightened inflammatory response against infection. This condition requires further exploration of biomarkers. We employed an "in silico" method comprised of text-mining and additionally clinical validation through the Medical Information Mart for Intensive Care. We highlight that Factor VIII shows potential as a pertinent septic shock biomarker..

引用

页码：1195 / 1196

页数：2

共 4 条

[1] MIMIC-III, a freely accessible critical care database [J].

Johnson, Alistair E. W. ;

Pollard, Tom J. ;

Shen, Lu ;

Lehman, Li-wei H. ;

Feng, Mengling ;

Ghassemi, Mohammad ;

Moody, Benjamin ;

Szolovits, Peter ;

Celi, Leo Anthony ;

Mark, Roger G. .

SCIENTIFIC DATA, 2016, 3

[2] An Integrative Biomedical Informatics Approach to Elucidate the Similarities Between Pre-Eclampsia and Hypertension [J].

Lopez-Campos, Guillermo ;

Bonner, Emma ;

McClements, Lana .

MEDINFO 2019: HEALTH AND WELLBEING E-NETWORKS FOR ALL, 2019, 264 :988-992

[3]

Polat G, 2017, EURASIAN J MED, V49, P53, DOI 10.5152/eurasianjmed.2017.17062

[4] PubTator: a web-based text mining tool for assisting biocuration [J].

Wei, Chih-Hsuan ;

Kao, Hung-Yu ;

Lu, Zhiyong .

NUCLEIC ACIDS RESEARCH, 2013, 41 (W1) :W518-W522

← 1 →