Cardio-Oncology An Update on Cardiotoxicity of Cancer-Related Treatment

被引：342

作者：

Lenneman, Carrie G. ^{[1
]}

Sawyer, Douglas B. ^{[2
]}

机构：

[1] Univ Louisville, Sch Med, Dept Med, Louisville, KY 40292 USA

[2] Maine Med Ctr, Cardiovasc Inst, Portland, ME USA

来源：

CIRCULATION RESEARCH | 2016年 / 118卷 / 06期

关键词：

cancer and stroke; cardiac dysfunction; cardiology; cardiotoxicity; oncology; ENDOTHELIAL GROWTH-FACTOR; LONG-TERM SURVIVORS; INDUCED HEART-DISEASE; ANTHRACYCLINE-INDUCED CARDIOTOXICITY; CHEMOTHERAPY-INDUCED CARDIOMYOPATHY; TRASTUZUMAB-RELATED CARDIOTOXICITY; ADVANCED BREAST-CANCER; CARDIOVASCULAR TOXICITY; MOLECULAR-BASIS; LUNG-CANCER;

D O I：

10.1161/CIRCRESAHA.115.303633

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Through the success of basic and disease-specific research, cancer survivors are one of the largest growing subsets of individuals accessing the healthcare system. Interestingly, cardiovascular disease is the second leading cause of morbidity and mortality in cancer survivors after recurrent malignancy. This recognition has helped stimulate a collaboration between oncology and cardiology practitioners and researchers, and the portmanteau cardio-oncology (also known as onco-cardiology) can now be found in many medical centers. This collaboration promises new insights into how cancer therapies impact cardiovascular homeostasis and long-term effects on cancer survivors. In this review, we will discuss the most recent views on the cardiotoxicity related to various classes of chemotherapy agents and radiation. We will also discuss broadly the current strategies for treating and preventing cardiovascular effects of cancer therapy.

引用

页码：1008 / 1020

页数：13

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