Clinical characteristics of COPD patients with tidal expiratory flow limitation

被引：28

作者：

Dean, James ^{[1
]}

Kolsum, Umme ^{[1
,2
,3
]}

Hitchen, Paul ^{[1
]}

Gupta, Vandana ^{[1
]}

Singh, Dave ^{[1
,2
,3
]}

机构：

[1] Med Evaluat Unit, Manchester, Lancs, England

[2] Univ Manchester, Div Infect Immun & Resp Med, Sch Biol Sci,Fac Biol Med & Hlth, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[3] Manchester NHS Fdn Trust, Univ Hosp South, Manchester, Lancs, England

来源：

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2017年 / 12卷

关键词：

COPD; expiratory flow limitation; IOS; small airway; reactance; OBSTRUCTIVE PULMONARY-DISEASE; STANDARDIZATION; LUNG; HYPERINFLATION;

D O I：

10.2147/COPD.S137865

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We have used impulse oscillometry to identify COPD patients with tidal expiratory flow limitation (EFL), which is a measurement related to small airway disease. We report that 37.4% of COPD patients had EFL; these patients had multiple clinical characteristics of more severe disease including lower forced expiratory volume in 1 second values, greater hyperinflation, reduced exercise performance, and increased small airway impairment. We highlight that EFL can be used to identify a subgroup of COPD patients with distinct characteristics associated with small airway disease.

引用

页码：1503 / 1506

页数：4

共 15 条

[1] Variability of within-breath reactance in COPD patients and its association with dyspnoea [J].

Aarli, Bernt B. ;

Calverley, Peter M. A. ;

Jensen, Robert L. ;

Eagan, Tomas M. L. ;

Bakke, Per S. ;

Hardie, Jon A. .

EUROPEAN RESPIRATORY JOURNAL, 2015, 45 (03) :625-634

[2] Treatable traits: toward precision medicine of chronic airway diseases [J].

Agusti, Alvar ;

Bel, Elisabeth ;

Thomas, Mike ;

Vogelmeier, Claus ;

Brusselle, Guy ;

Holgate, Stephen ;

Humbert, Marc ;

Jones, Paul ;

Gibson, Peter G. ;

Vestbo, Jorgen ;

Beasley, Richard ;

Pavord, Ian D. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :410-419

[3] Impulse Oscillometry Interpretation and Practical Applications [J].

Bickel, Scott ;

Popler, Jonathan ;

Lesnick, Burton ;

Eid, Nemr .

CHEST, 2014, 146 (03) :841-847

[4]

Dellacà RL, 2004, EUR RESPIR J, V23, P232, DOI 10.1183/09031936.04.00046804

[5] Pathogenesis of hyperinflation in chronic obstructive pulmonary disease [J].

Gagnon, Philippe ;

Guenette, Jordan A. ;

Langer, Daniel ;

Laviolette, Louis ;

Mainguy, Vincent ;

Maltais, Francois ;

Ribeiro, Fernanda ;

Saey, Didier .

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2014, 9 :187-201

[6] The nature of small-airway obstruction in chronic obstructive pulmonary disease [J].

Hogg, JC ;

Chu, F ;

Utokaparch, S ;

Woods, R ;

Elliott, WM ;

Buzatu, L ;

Cherniack, RM ;

Rogers, RM ;

Sciurba, FC ;

Coxson, HO ;

Paré, PD .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (26) :2645-2653

[7] Expiratory flow limitation relates to symptoms during COPD exacerbations requiring hospital admission [J].

Jetmalani, Kanika ;

Timmins, Sophie ;

Brown, Nathan J. ;

Diba, Chantale ;

Berend, Norbert ;

Salome, Cheryl M. ;

Wen, Fu-Qiang ;

Chen, Peng ;

King, Gregory G. ;

Farah, Claude S. .

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2015, 10 :939-945

[8] Standardisation of the single-breath determination of carbon monoxide uptake in the lung [J].

MacIntyre, N ;

Crapo, RO ;

Viegi, G ;

Johnson, DC ;

van der Grinten, CPM ;

Brusasco, V ;

Burgos, F ;

Casaburi, R ;

Coates, A ;

Enright, P ;

Gustafsson, P ;

Hankinson, J ;

Jensen, R ;

McKay, R ;

Miller, MR ;

Navajas, D ;

Pedersen, OF ;

Pellegrino, R ;

Wanger, J .

EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (04) :720-735

[9] Standardisation of spirometry [J].

Miller, MR ;

Hankinson, J ;

Brusasco, V ;

Burgos, F ;

Casaburi, R ;

Coates, A ;

Crapo, R ;

Enright, P ;

van der Grinten, CPM ;

Gustafsson, P ;

Jensen, R ;

Johnson, DC ;

MacIntyre, N ;

McKay, R ;

Navajas, D ;

Pedersen, OF ;

Pellegrino, R ;

Viegi, G ;

Wanger, J .

EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (02) :319-338

[10] Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum [J].

Ravi, Arjun K. ;

Khurana, Shruti ;

Lemon, Jonathan ;

Plumb, Jonathan ;

Booth, George ;

Healy, Louise ;

Catley, Matthew ;

Vestbo, Jorgen ;

Singh, Dave .

RESPIRATORY RESEARCH, 2014, 15

← 1 2 →