Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

被引：77

作者：

Cao, Yubin ^{[2
,3
]}

Li, Zeping ^{[2
,3
]}

Jiang, Wenyu ^{[2
,3
]}

Ling, Yan ^{[4
]}

Kuang, Haibin ^{[1
,2
,5
]}

机构：

[1] Nanchang Univ, Med Expt Teaching Ctr, Jiangxi Prov Key Lab Reprod Physiol & Pathol, Aff4, Nanchang, Jiangxi, Peoples R China

[2] Nanchang Univ, Basic Med Coll, Dept Physiol, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Sch Queen Mary, Dept Clin Med, Nanchang 330006, Jiangxi, Peoples R China

[4] Jiangxi Prov Peoples Hosp, Dept Obstet & Gynecol, Nanchang 330006, Jiangxi, Peoples R China

[5] Nanchang Univ, Med Expt Teaching Ctr, Jiangxi Prov Key Lab Reprod Physiol & Pathol, Nanchang 330006, Jiangxi, Peoples R China

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2019年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Kisspeptin; KISS1R; Ovary; Testis; Uterus; Placenta; METASTASIS SUPPRESSOR GENE; PROTEIN-COUPLED RECEPTOR; GONADOTROPIN-INHIBITORY HORMONE; PROGESTERONE SECRETION; SIGNALING PATHWAY; KISS1(-/-) MICE; ESTROUS-CYCLE; NEUROKININ B; IN-VITRO; EXPRESSION;

D O I：

10.1186/s12958-019-0511-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.

引用

页数：9

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