Individual Susceptibility to Occupational Contact Dermatitis

被引：36

作者：

Kezic, Sanja ^{[1
]}

Visser, Maaike J. ^{[1
]}

Verberk, Maarten M. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Inst Occupat Hlth, NL-1100 DE Amsterdam, Netherlands

来源：

INDUSTRIAL HEALTH | 2009年 / 47卷 / 05期

关键词：

Susceptibility; Contact dermatitis; Occupational; Filaggrin; Cytokines; Genetic polymorphisms; Skin barrier; Atopy; SODIUM LAURYL SULFATE; PROSPECTIVELY-FOLLOWED COHORT; CYTOKINE GENE POLYMORPHISMS; OF-FUNCTION MUTATIONS; EPIDERMAL WATER-LOSS; HAND ECZEMA; ATOPIC-DERMATITIS; UNINVOLVED SKIN; FILAGGRIN GENE; PATCH-TEST;

D O I：

10.2486/indhealth.47.469

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Occupational Contact Dermatitis (OCD) is one of the most common work-related diseases. High risk occupations are in health care, hairdressing, food sector and metal industry. OCD tends to become chronic; persistent OCD often results in impaired quality of life and loss of work ability. The purpose of this article is to review the present knowledge on the factors which determine individual susceptibility to acquire OCD. Recent discoveries regarding genes involved in the skin barrier, inflammatory response and biotransformation of xenobiotics provide more insight in the individual susceptibility for OCD. Knowledge of the factors which predispose to OCD is useful in occupational health practice for the application of preventive measures and for career guidance for apprentices and workers in high risk occupations.

引用

页码：469 / 478

页数：10

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