New treatment for invasive fungal sinusitis: Three cases of chronic invasive fungal sinusitis treated with surgery and voriconazole

被引：14

作者：

Nakaya, Kazuhiro ^{[1
]}

Oshima, Takeshi ^{[1
]}

Kudo, Takayuki ^{[1
]}

Aoyagi, Iori ^{[1
]}

Katori, Yukio ^{[1
]}

Ota, Jun ^{[1
]}

Hidaka, Hiroshi ^{[1
]}

Oda, Kiyoshi ^{[1
]}

Kobayashi, Toshimitsu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

AURIS NASUS LARYNX | 2010年 / 37卷 / 02期

关键词：

Chronic invasive fungal sinusitis; Voriconazole; Amphotericin B; AMPHOTERICIN-B; ASPERGILLOSIS; INFECTIONS; THERAPY; AGENTS;

D O I：

10.1016/j.anl.2009.05.006

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Invasive fungal sinusitis is a relatively rare disease and can be divided into acute fulminant, chronic, and granulomatous invasive fungal sinusitis. The conventional treatment is radical surgery combined with systemic amphotericin B administration, but the poor prognosis and unesablished treatment options require a better therapeutic strategy. We report three cases of chronic invasive fungal sinustis successfully treated with a combination of surgery and voriconazole, a new antifungal agent, with good responses in all patients. Voriconazole adminsitration could form the basis for a new standard treatment for invasive fungal sinusitis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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页码：244 / 249

页数：6

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