Two New 5-Oxomilbemycins Possessing an Unusual 3,27-Epoxy Bond from the Genetically Engineered Strain Streptomyces bingchenggensis BCJ60

被引：2

作者：

Hao, Zhi-Kui ^{[1
]}

Li, Jian-Song ^{[1
]}

Wang, Ji-Dong ^{[2
]}

Xiang, Wen-Sheng ^{[3
]}

Wang, Hai-Yan ^{[3
]}

机构：

[1] Taizhou Vocat & Tech Coll, Inst Appl Biotechnol, Sch Med & Pharmaceut Engn, Taizhou 318000, Peoples R China

[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China

[3] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150000, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2021年 / 57卷 / 02期

关键词：

genetically engineered strain; Streptomyces bingchenggensis BCJ60; milbemycin derivatives; acaricidal and nematocidal activities;

D O I：

10.1007/s10600-021-03339-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two undescribed milbemycin derivatives, milbemycin P (1) and milbemycin Q (2), were isolated from a culture of the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. Their acaricidal and nematocidal activities against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1-2 possessed potent acaricidal and nematocidal activities.

引用

页码：289 / 292

页数：4

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