By word of mouse: using animal models in venous thrombosis research

被引：18
作者：
Campos, Joana [1 ]
Brill, Alexander [1 ,2 ,3 ,4 ]
机构：
[1] Univ Birmingham, Inst Cardiovasc Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England
[2] Sechenov First Moscow State Med Univ, Dept Pathophysiol, Sechenov Univ, Moscow, Russia
[3] Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, The Midlands, England
[4] Univ Nottingham, Ctr Membrane Prot & Receptors COMPARE, The Midlands, England
来源：
PLATELETS | 2020年 / 31卷 / 04期
关键词：
Animal models; deep vein thrombosis; pulmonary embolism; DEEP-VEIN THROMBOSIS; INFERIOR VENA-CAVA; CONTINUOUS BLOOD-FLOW; FACTOR-V-LEIDEN; MURINE MODEL; PULMONARY-EMBOLISM; PROTEIN-C; MICE; GENE; MECHANISMS;
D O I：
10.1080/09537104.2019.1678117
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Deep vein thrombosis (DVT) is a disease with high prevalence and morbidity. It can lead to pulmonary embolism with severe respiratory insufficiency and risk of death. Mechanisms behind all stages of DVT, such as thrombosis commencement, propagation, and resolution, remain incompletely understood. Animal models represent an invaluable tool to explore these problems and identify new targets for DVT prevention and treatment. In this review, we discuss existing models of venous thrombosis, their advantages and disadvantages, and applicability to studying different aspects of DVT pathophysiology. We also speculate about requirements for an ?ideal model? that would best recapitulate features of human DVT and discuss readouts of various models.
引用
收藏
页码：447 / 454
页数：8
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