By word of mouse: using animal models in venous thrombosis research

被引：18
作者：
Campos, Joana [1 ]
Brill, Alexander [1 ,2 ,3 ,4 ]
机构：
[1] Univ Birmingham, Inst Cardiovasc Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England
[2] Sechenov First Moscow State Med Univ, Dept Pathophysiol, Sechenov Univ, Moscow, Russia
[3] Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, The Midlands, England
[4] Univ Nottingham, Ctr Membrane Prot & Receptors COMPARE, The Midlands, England
来源：
PLATELETS | 2020年 / 31卷 / 04期
关键词：
Animal models; deep vein thrombosis; pulmonary embolism; DEEP-VEIN THROMBOSIS; INFERIOR VENA-CAVA; CONTINUOUS BLOOD-FLOW; FACTOR-V-LEIDEN; MURINE MODEL; PULMONARY-EMBOLISM; PROTEIN-C; MICE; GENE; MECHANISMS;
D O I：
10.1080/09537104.2019.1678117
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Deep vein thrombosis (DVT) is a disease with high prevalence and morbidity. It can lead to pulmonary embolism with severe respiratory insufficiency and risk of death. Mechanisms behind all stages of DVT, such as thrombosis commencement, propagation, and resolution, remain incompletely understood. Animal models represent an invaluable tool to explore these problems and identify new targets for DVT prevention and treatment. In this review, we discuss existing models of venous thrombosis, their advantages and disadvantages, and applicability to studying different aspects of DVT pathophysiology. We also speculate about requirements for an ?ideal model? that would best recapitulate features of human DVT and discuss readouts of various models.
引用
收藏
页码：447 / 454
页数：8
相关论文
共 99 条
  • [1] In vivo monitoring of venous thrombosis in mice
    Aghourian, M. N.
    Lemarie, C. A.
    Blostein, M. D.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (03) : 447 - 452
  • [2] Fibrin-Targeted Magnetic Resonance Imaging Allows In Vivo Quantification of Thrombus Fibrin Content and Identifies Thrombi Amenable for Thrombolysis
    Andia, Marcelo E.
    Saha, Prakash
    Jenkins, Julia
    Modarai, Bijan
    Wiethoff, Andrea J.
    Phinikaridou, Alkystis
    Grover, Steven P.
    Patel, Ashish S.
    Schaeffter, Tobias
    Smith, Alberto
    Botnar, Rene M.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (06) : 1193 - 1198
  • [3] Pre-Clinical Model to Study Recurrent Venous Thrombosis in the Inferior Vena Cava
    Andraska, Elizabeth A.
    Luke, Catherine E.
    Elfline, Megan A.
    Henke, Samuel P.
    Madapoosi, Siddharth S.
    Metz, Allan K.
    Hoinville, Megan E.
    Wakefield, Thomas W.
    Henke, Peter K.
    Diaz, Jose A.
    [J]. THROMBOSIS AND HAEMOSTASIS, 2018, 118 (06) : 1048 - 1057
  • [4] Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation
    Banno, Fumiaki
    Kita, Toshiyuki
    Fernandez, Jose A.
    Yanamoto, Hiroji
    Tashima, Yuko
    Kokame, Koichi
    Griffin, John H.
    Miyata, Toshiyuki
    [J]. BLOOD, 2015, 126 (19) : 2247 - 2253
  • [5] The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice
    Bochenek, Magdalena L.
    Bauer, Tobias
    Gogiraju, Rajinikanth
    Nadir, Yona
    Mann, Amrit
    Schoenfelder, Tanja
    Huenig, Leonie
    Brenner, Benjamin
    Muenzel, Thomas
    Wenzel, Philip
    Konstantinides, Stavros
    Schaefer, Katrin
    [J]. BLOOD ADVANCES, 2018, 2 (11) : 1300 - 1314
  • [6] Venous Valvular Stasis-Associated Hypoxia and Thrombosis: What Is the Link?
    Bovill, Edwin G.
    van der Vliet, Albert
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, VOL 73, 2011, 73 : 527 - 545
  • [7] Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice
    Brandt, Moritz
    Giokoglu, Eleni
    Garlapati, Venkata
    Bochenek, Madgalena L.
    Molitor, Michael
    Hobohm, Lukas
    Schoenfelder, Tanja
    Muenzel, Thomas
    Kossmann, Sabine
    Karbach, Susanne H.
    Schaefer, Katrin
    Wenzel, Philip
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
  • [8] Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches
    Brandt, Moritz
    Schoenfelder, Tanja
    Schwenk, Melanie
    Becker, Christian
    Jaeckel, Sven
    Reinhardt, Christoph
    Stark, Konstantin
    Massberg, Steffen
    Muenzel, Thomas
    von Bruehl, Marie-Luise
    Wenzel, Philip
    [J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2014, 56 (02) : 145 - 152
  • [9] Neutrophil extracellular traps promote deep vein thrombosis in mice
    Brill, A.
    Fuchs, T. A.
    Savchenko, A. S.
    Thomas, G. M.
    Martinod, K.
    De Meyer, S. F.
    Bhandari, A. A.
    Wagner, D. D.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (01) : 136 - 144
  • [10] Extrahepatic High-Density Lipoprotein Receptor SR-BI and ApoA-I Protect Against Deep Vein Thrombosis in Mice
    Brill, Alexander
    Yesilaltay, Ayce
    De Meyer, Simon F.
    Kisucka, Janka
    Fuchs, Tobias A.
    Kocher, Olivier
    Krieger, Monty
    Wagner, Denisa D.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (08) : 1841 - U308
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