Tissue Healing during Degradation of a Long-Lasting Bioresorbable γ-Ray-Sterilised Poly(Lactic Acid) Mesh in the Rat: A 12-Month Study

被引：10
作者：
de Tayrac, R. [1 ,3 ]
Letouzey, V. [1 ,3 ]
Garreau, H. [3 ]
Guiraud, I. [2 ]
Vert, M. [3 ]
Mares, P. [1 ]
机构：
[1] Caremeau Univ Hosp, Obstet & Gynaecol Dept, Nimes, France
[2] Montpellier Nimes Med Univ, Histol Embryol Cytogenet Lab, Nimes, France
[3] Univ Pharm, CNRS, IBMM 5473, Montpellier, France
来源：
EUROPEAN SURGICAL RESEARCH | 2010年 / 44卷 / 02期
关键词：
Animal study; Genital prolapse repair; Poly(lactic acid) mesh; Polypropylene mesh; Tissue healing; PELVIC SUPPORT DEFECTS; ABDOMINAL-WALL DEFECTS; ANTERIOR COLPORRHAPHY; RANDOMIZED TRIAL; REPAIR; BIOCOMPATIBILITY; RECONSTRUCTION; REINFORCEMENT; SUSPENSION; PROLAPSE;
D O I：
10.1159/000277933
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Aim: The purpose was to evaluate soft-tissue healing after poly(lactic acid) (PLA(94)) mesh implantation in a rat model. Methods: Full-thickness abdominal wall defects were created in 108 Wistar rats, and reconstructed with 83 PLA(94) and 25 lightweight polypropylene (PPL) meshes. The meshes were previously gamma-ray sterilised with 25, 75 or 125 kGy to accelerate PLA(94) degradation. Results: The inflammatory response in PLA(94) was significantly less pronounced and collagen organisation significantly better than in PPL. The higher the level of gamma-radiation, the higher the incidence of abdominal wall herniation (22.2, 31.3 and 52.6% with 25, 75 and 125 kGy, respectively). No herniation occurred in the PPL group. Tensile strength was dramatically reduced after gamma-ray-sterilised PLA(94) mesh implantation. Conclusion: The gamma-ray-sterilised PLA(94) mesh was poor in preventing abdominal wall hernia recurrences in a rat model. Copyright (C) 2010 S. Karger AG, Basel
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收藏
页码：102 / 110
页数：9
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