Why bicarbonate?

被引：71
作者：
Casey, Joseph R. [1 ]
机构：
[1] Univ Alberta, Dept Physiol, Membrane Prot Res Grp, Edmonton, AB T6G 2H7, Canada
[2] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada
来源：
BIOCHEMISTRY AND CELL BIOLOGY | 2006年 / 84卷 / 06期
关键词：
bicarbonate transport; pH regulation; bicarbonate metabolism;
D O I：
10.1139/O06-184
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in diverse biological processes. Among these are photosynthesis, the Krebs cycle, whole-body and cellular pH regulation, and volume regulation. Since bicarbonate is charged it is not permeable to lipid bilayers. Mammalian membranes thus contain bicarbonate transport proteins to facilitate the specific transmembrane movement of HCO3-. This review provides a wide-ranging view of the biochemistry of bicarbonate and its membrane transporters, revealing what makes the study of bicarbonate transport such a rewarding activity.
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收藏
页码：930 / 939
页数：10
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