Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN3, and Ethers: Regiocontrollable Synthesis of N1- and N2-Oxyalkylated 1,2,3-Triazoles

被引：42

作者：

Bao, Pengli ^{[1
]}

Yue, Huilan ^{[2
,3
]}

Meng, Na ^{[1
]}

Zhao, Xiaohui ^{[2
,3
]}

Li, Jiangsheng ^{[4
]}

Wei, Wei ^{[1
,2
,3
]}

机构：

[1] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[3] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[4] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Changsha 410114, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 18期

基金：

中国国家自然科学基金;

关键词：

INTERRUPTED CLICK REACTION; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; 3+2 CYCLOADDITION; CASCADE REACTION; TRIAZOLE; AZIDES; FUNCTIONALIZATION; AZOLES; TETRAHYDROFURAN;

D O I：

10.1021/acs.orglett.9b02295

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new copper-catalyzed selective synthesis of N-1- and N-2-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN3, and ethers. Through this methodology, a series of N-1- and N-2- oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively obtained from simple and readily available starting materials with favorable functional group tolerance.

引用

页码：7218 / 7222

页数：5

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