Low serum 25(OH)D levels are associated to higher BMI and metabolic syndrome parameters in adult subjects in Turkey

Background: The aim of this study was to investigate the association of 25(OH) D levels with biochemical, anthropometric, and metabolic data obtained from normal and obese people. Methods: This study was carried out on 90 individuals between the ages of 18 to 63 that had various body mass indexes. Blood samples and anthropometric measurements were taken. Results: Waist circumferences, fat mass, LDL cholesterol levels, HDL cholesterol levels, 25(OH) D levels, and triglyceride levels were significantly different according to the body mass index groups of the participants (p<0.05). When compared to the normal body mass index group, both other groups (overweight and obese) had higher waist circumferences, triglyceride levels, LDL cholesterol levels, fasting insulin levels, HOMA-IR ratios, parathyroid hormone levels, and fat mass, and had lower 25(OH) D levels (p<0.05). The overweight group participants had higher 25(OH) D levels than the obese group, and had lower waist circumferences, fat mass, fasting insulin level, HOMA-IR ratios, and HbA1C and PTH levels than those in the obese group (p<0.05). Conclusion: In conclusion, the mean level of 25(OH) D is very low in overweight and obese individuals and low serum 25(OH) D levels appear to be associated with obesity, visceral obesity, hypertriglyceridemia, insulin resistance, and metabolic syndrome in obese patients.