SIMULATION OF A DNA DENATURATION PROCESS

被引:0
作者
Ines, Tomas R. [1 ]
Cisneros, Francisco J. [1 ]
Goni, Angel [1 ]
Castellanos, Juan [2 ]
机构
[1] Univ Politecn Madrid, Nat Comp Grp, Madrid 28660, Spain
[2] Univ Politecn Madrid, Fac Informat, Dept Artificial Intelligence, E-28660 Madrid, Spain
来源
2009 IEEE/ACS INTERNATIONAL CONFERENCE ON COMPUTER SYSTEMS AND APPLICATIONS, VOLS 1 AND 2 | 2009年
关键词
DNA Computing; DNA Simulation; THERMODYNAMICS;
D O I
10.1109/AICCSA.2009.5069409
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
DNA computing is an emerging research area that needs software simulators in order to avoid working with DNA in-vitro. The purpose of this paper is to present a computer program which simulates a denaturation process of DNA molecules. This simulation represents a useful tool for a virtual laboratory which is oriented to DNA computations. The method used is based on the entropy and enthalpy of the nitrogenous bases like a way to determinate the suitable fusion temperatures of the molecules. The results given by the software can show the behaviour of a DNA strand under certain physical conditions which allow us to compare the resistance of DNA molecules when a denaturation process occurs.
引用
收藏
页码:737 / +
页数:2
相关论文
共 10 条
[1]   MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].
ADLEMAN, LM .
SCIENCE, 1994, 266 (5187) :1021-1024
[2]  
BANOS R, 2008, P 2 C META 08
[3]  
BRIIDERLE D, 2007, SOFTWARE FRAMEWORK T
[4]   ENTROPY-DRIVEN TRANSITION IN A ONE-DIMENSIONAL SYSTEM [J].
DAUXOIS, T ;
PEYRARD, M .
PHYSICAL REVIEW E, 1995, 51 (05) :4027-4040
[5]   ENTROPY-DRIVEN DNA DENATURATION [J].
DAUXOIS, T ;
PEYRARD, M ;
BISHOP, AR .
PHYSICAL REVIEW E, 1993, 47 (01) :R44-R47
[6]   THERMODYNAMICS OF A NONLINEAR MODEL FOR DNA DENATURATION [J].
DAUXOIS, T ;
PEYRARD, M ;
BISHOP, AR .
PHYSICA D, 1993, 66 (1-2) :35-42
[7]   From bits to bases: Computing with DNA [J].
Dove, A .
NATURE BIOTECHNOLOGY, 1998, 16 (09) :830-832
[8]  
LEWIN B, 2005, GENES, V8
[9]   EMBOSS: The European molecular biology open software suite [J].
Rice, P ;
Longden, I ;
Bleasby, A .
TRENDS IN GENETICS, 2000, 16 (06) :276-277