Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

被引：48

作者：

Madden, David J. ^{[1
,2
]}

Parks, Emily L. ^{[1
,2
]}

Tallman, Catherine W. ^{[1
]}

Boylan, Maria A. ^{[1
]}

Hoagey, David A. ^{[1
]}

Cocjin, Sally B. ^{[1
]}

Packard, Lauren E. ^{[1
]}

Johnson, Micah A. ^{[1
]}

Chou, Ying-hui ^{[1
,2
]}

Potter, Guy G. ^{[1
,2
]}

Chen, Nan-kuei ^{[1
,3
]}

Siciliano, Rachel E. ^{[1
]}

Monge, Zachary A. ^{[4
]}

Honig, Jesse A. ^{[1
]}

Diaz, Michele T. ^{[5
]}

机构：

[1] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Box 3918, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

[3] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA

[4] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA

[5] Penn State Univ, Dept Psychol, University Pk, PA 16802 USA

来源：

NEUROBIOLOGY OF AGING | 2017年 / 54卷

关键词：

Magnetic resonance imaging; Diffusion tensor imaging; Cognition; Cortex; Mediation; ADULT AGE-DIFFERENCES; PROCESSING-SPEED; COGNITIVE FUNCTIONS; CORTICAL THICKNESS; EXECUTIVE FUNCTION; BRAIN SYSTEMS; DECLINE; MRI; MEDIATION; NETWORKS;

D O I：

10.1016/j.neurobiolaging.2017.01.027

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：199 / 213

页数：15

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