Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

被引：48
作者：
Madden, David J. [1 ,2 ]
Parks, Emily L. [1 ,2 ]
Tallman, Catherine W. [1 ]
Boylan, Maria A. [1 ]
Hoagey, David A. [1 ]
Cocjin, Sally B. [1 ]
Packard, Lauren E. [1 ]
Johnson, Micah A. [1 ]
Chou, Ying-hui [1 ,2 ]
Potter, Guy G. [1 ,2 ]
Chen, Nan-kuei [1 ,3 ]
Siciliano, Rachel E. [1 ]
Monge, Zachary A. [4 ]
Honig, Jesse A. [1 ]
Diaz, Michele T. [5 ]
机构：
[1] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Box 3918, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
[4] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA
[5] Penn State Univ, Dept Psychol, University Pk, PA 16802 USA
来源：
NEUROBIOLOGY OF AGING | 2017年 / 54卷
关键词：
Magnetic resonance imaging; Diffusion tensor imaging; Cognition; Cortex; Mediation; ADULT AGE-DIFFERENCES; PROCESSING-SPEED; COGNITIVE FUNCTIONS; CORTICAL THICKNESS; EXECUTIVE FUNCTION; BRAIN SYSTEMS; DECLINE; MRI; MEDIATION; NETWORKS;
D O I：
10.1016/j.neurobiolaging.2017.01.027
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：199 / 213
页数：15
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