Upper limit for angular compounding speckle reduction

被引:5
|
作者
Winetraub, Yonatan [1 ,2 ,3 ,4 ]
Wu, Chris [2 ,3 ]
Collins, Graham P. [2 ,3 ]
Chu, Steven [1 ,4 ,5 ,6 ]
de la Zerda, Adam [1 ,2 ,3 ,4 ,7 ]
机构
[1] Biophys Program, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Struct Biol, Stanford, CA 94305 USA
[3] Mol Imaging Program, Stanford, CA 94305 USA
[4] Bio X Program, Stanford, CA 94305 USA
[5] Stanford Univ, Dept Phys, Stanford, CA 94305 USA
[6] Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
[7] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
OPTICAL COHERENCE TOMOGRAPHY;
D O I
10.1063/1.5088709
中图分类号
O59 [应用物理学];
学科分类号
摘要
Angular compounding is a technique for reducing speckle noise in optical coherence tomography that is claimed to significantly improve the signal-to-noise ratio (SNR) of images without impairing their spatial resolution. Here, we examine how focal point movements caused by optical aberrations in an angular compounding system may produce unintended spatial averaging and concomitant loss of spatial resolution. Experimentally, we accounted for such aberrations by aligning our system and measuring distortions in images and found that when the distortions were corrected, the speckle reduction by angular compounding was limited. Our theoretical analysis using Monte Carlo simulations indicates that pure angular compounding (i.e., with no spatial averaging) over our full numerical aperture (13 degrees in air) can improve the SNR by not more than a factor of 1.3. Illuminating only a partial aperture cannot improve this factor compared to a spatial averaging system with equivalent loss of resolution. We conclude that speckle reduction using angular compounding is equivalent to spatial averaging. Nonetheless, angular compounding may be useful for improving images in applications where the depth of field is important. The distortions tend to be the greatest off the focal plane, and so angular compounding combined with our correction technique can reduce speckle with a minimal loss of resolution across a large depth of field.
引用
收藏
页数:5
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