Exercise-Induced Autophagy in Fatty Liver Disease

被引：24

作者：

Chun, Sung Kook ^{[1
]}

Lee, Sooyeon ^{[1
]}

Yang, Ming-Jim ^{[1
]}

Leeuwenburgh, Christiaan ^{[2
]}

Kim, Jae-Sung ^{[1
]}

机构：

[1] Univ Florida, Dept Surg, R4-204 ARB,1600 SW Archer Rd, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2017年 / 45卷 / 03期

基金：

美国国家卫生研究院;

关键词：

nonalcoholic fatty liver disease; liver; lipids; exercise; autophagy; mitochondria; mitophagy; MITOCHONDRIAL PERMEABILITY TRANSITION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; CALORIE RESTRICTION; HEPATIC STEATOSIS; CELL-SURVIVAL; MICE; OBESITY; MASS; ASSOCIATION;

D O I：

10.1249/JES.0000000000000116

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.

引用

页码：181 / 186

页数：6

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