Cascade Michael-Aldol reactions promoted by hydrogen bonding mediated catalysis

被引：254

作者：

Zu, Liansuo ^{[1
]}

Wang, Jian ^{[1
]}

Li, Hao ^{[1
]}

Xie, Hexin ^{[1
]}

Jiang, Wei ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 05期

关键词：

D O I：

10.1021/ja067781+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantio- and diastereoselective tandem Michael-aldol reactions, efficiently catalyzed by a cinchona alkaloid thiourea via synergistic noncovalent hydrogen-bonding activation of both the Michael donor and acceptor, have been developed. The process affords a powerful means for the construction of versatile chiral thiochromanes with the formation of three stereogenic centers in a one-pot synthesis from simple achiral compounds.

引用

页码：1036 / 1037

页数：2

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