Studies and analytical application of reaction of imipramine with chrome azurol S

被引：6
作者：
Starczewska, B [1 ]
Halaburda, P [1 ]
Kojlo, A [1 ]
机构：
[1] Univ Bialystok, Inst Chem, PL-15443 Bialystok, Poland
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 30卷 / 03期
关键词：
imipramine; chrome azurol S; extractive spectrophotometric analysis; flow injection analysis;
D O I：
10.1016/S0731-7085(02)00314-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Chrome azurol S (CAS) was tested as a spcctrophotometric reagent for the determination of imipramine (IMP). It reacts in aqueous media with IMP forming pink-red, sparingly soluble in water ion association compound. This compound was quantitatively extracted with chloroform and the absorbance of organic phase was measured at 510 nm. The extraction conditions were studied using a batch method. On the basis of the results obtained with batch method, three-line flow-injection system was constructed. Batch and flow-injection methods were successfully applied for the determination of IMP in pharmaceutical preparation. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：553 / 560
页数：8
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