Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

被引：329

作者：

Gholap, Somnath S. ^{[1
]}

机构：

[1] Padmashri Vikhe Patil Coll, Dept Chem, Ahmednagar 413713, Maharashtra, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 110卷

关键词：

N-substituted pyrrole; Fused pyrroles; Natural pyrrole derivatives; Therapeutic agents; BIOLOGICAL EVALUATION; IN-VITRO; ANTIMICROBIAL ACTIVITY; INHIBITING ACTIVITY; NITRIC-OXIDE; DERIVATIVES; POTENT; DESIGN; ANTICANCER; DISCOVERY;

D O I：

10.1016/j.ejmech.2015.12.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：13 / 31

页数：19

共 78 条

[51] Design, synthesis and anti-mycobacterial activity of 1,2,3,5-tetrasubstituted pyrrolyl-N-acetic acid derivatives [J].

Pagadala, Lakshmi Reddy ;

Mukkara, Lakshmi Devi ;

Singireddi, Satyanarayana ;

Singh, Ashita ;

Thummaluru, Veera Reddy ;

Jagarlamudi, Padma Sridevi ;

Guttala, Raja Sekhar ;

Perumal, Yogeeswari ;

Dharmarajan, Sriram ;

Upadhyayula, Suryanarayana Murty ;

Ummanni, Ramesh ;

Basireddy, Venkata Subba Reddy ;

Ravirala, Narender .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 84 :118-126

[52] Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity [J].

Parrino, Barbara ;

Carbone, Anna ;

Spano, Virginia ;

Montalbano, Alessandra ;

Giallombardo, Daniele ;

Barraja, Paola ;

Attanzio, Alessandro ;

Tesoriere, Luisa ;

Sissi, Claudia ;

Palumbo, Manlio ;

Cirrincione, Girolamo ;

Diana, Patrizia .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 94 :367-377

[53] Water-soluble isoindolo[2,1-a] quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action [J].

Parrino, Barbara ;

Carbone, Anna ;

Ciancimino, Cristina ;

Spano, Virginia ;

Montalbano, Alessandra ;

Barraja, Paola ;

Cirrincione, Girolamo ;

Diana, Patrizia ;

Sissi, Claudia ;

Palumbo, Manlio ;

Pinato, Odra ;

Pennati, Marzia ;

Beretta, Giovanni ;

Folini, Marco ;

Matyus, Peter ;

Balogh, Balazs ;

Zaffaroni, Nadia .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 94 :149-162

[54] Identification of Thieno[3,2-b]Pyrrole Derivatives as Novel Small Molecule Inhibitors of Neurotropic Alphaviruses [J].

Peng, Weiping ;

Peltier, Daniel C. ;

Larsen, Martha J. ;

Kirchhoff, Paul D. ;

Larsen, Scott D. ;

Neubig, Richard R. ;

Miller, David J. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (07) :950-957

[55] Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF) [J].

Perdih, Andrej ;

Hrast, Martina ;

Barreteau, Helene ;

Gobec, Stanislav ;

Wolber, Gerhard ;

Solmajer, Tom .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (15) :4124-4134

[56] 3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles:: A new class of CDK2 inhibitors [J].

Pevarello, P ;

Fancelli, D ;

Vulpetti, A ;

Amici, R ;

Villa, M ;

Pittalà, V ;

Vianello, P ;

Cameron, A ;

Ciomei, M ;

Mercurio, C ;

Bischoff, JR ;

Roletto, F ;

Varasi, M ;

Brasca, MG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (04) :1084-1090

[57] 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands [J].

Piscitelli, Francesco ;

Ligresti, Alessia ;

La Regina, Giuseppe ;

Gatti, Valerio ;

Brizzi, Antonella ;

Pasquini, Serena ;

Allara, Marco ;

Carai, Mauro Antonio Maria ;

Novellino, Ettore ;

Colombo, Giancarlo ;

Di Marzo, Vincenzo ;

Corelli, Federico ;

Silvestri, Romano .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) :5641-5653

[58] New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae [J].

Pullen, C ;

Schmitz, P ;

Meurer, K ;

Bamberg, DDV ;

Lohmann, S ;

França, SDC ;

Groth, I ;

Schlegel, B ;

Möllmann, U ;

Gollmick, F ;

Gräfe, U ;

Leistner, E .

PLANTA, 2002, 216 (01) :162-167

[59] Synthesis of novel 4-nitropyrrole-based semicarbazide and thiosemicarbazide hybrids with antimicrobial and anti-tubercular activity [J].

Rane, Rajesh A. ;

Naphade, Shital S. ;

Bangalore, Pavan Kumar ;

Palkar, Mahesh B. ;

Shaikh, Mahamadhanif S. ;

Karpoormath, Rajshekhar .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (14) :3079-3083

[60]

Rango R., 2008, EUR J MED CHEM, V43, P621

← 1 2 3 4 5 6 7 8 →