Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

被引：310
作者：
Gholap, Somnath S. [1 ]
机构：
[1] Padmashri Vikhe Patil Coll, Dept Chem, Ahmednagar 413713, Maharashtra, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 110卷
关键词：
N-substituted pyrrole; Fused pyrroles; Natural pyrrole derivatives; Therapeutic agents; BIOLOGICAL EVALUATION; IN-VITRO; ANTIMICROBIAL ACTIVITY; INHIBITING ACTIVITY; NITRIC-OXIDE; DERIVATIVES; POTENT; DESIGN; ANTICANCER; DISCOVERY;
D O I：
10.1016/j.ejmech.2015.12.017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics. (C) 2015 Elsevier Masson SAS. All rights reserved.
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收藏
页码：13 / 31
页数：19
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