Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

被引:207
作者
Nosrati, Hamed [1 ]
Aramideh Khouy, Reza [2 ]
Nosrati, Ali [3 ]
Khodaei, Mohammad [4 ]
Banitalebi-Dehkordi, Mehdi [5 ]
Ashrafi-Dehkordi, Korosh [5 ]
Sanami, Samira [6 ]
Alizadeh, Zohreh [7 ,8 ]
机构
[1] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Tissue Engn & Appl Cell Sci, Shahrekord, Iran
[2] Iran Univ Med Sci, Dept Virol, Tehran, Iran
[3] Univ Tehran, Sch Mech Engn, Coll Engn, Tehran, Iran
[4] Golpayegan Univ Technol, Dept Mat Sci & Engn, Golpayegan, Iran
[5] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Mol Med, Shahrekord, Iran
[6] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord, Iran
[7] Hamadan Univ Med Sci, Endometrium & Endometriosis Res Ctr, Hamadan, Hamadan, Iran
[8] Hamadan Univ Med Sci, Sch Med, Dept Anat Sci, Hamadan, Hamadan, Iran
关键词
Scaffold; Angiogenesis; Chronic wound; Wound healing; Skin tissue engineering; Nanobiotechnology; ENDOTHELIAL GROWTH-FACTOR; BIOACTIVE GLASS NANOPARTICLES; CERIUM OXIDE NANOPARTICLES; CARBON NANOTUBES; GRAPHENE OXIDE; IN-VITRO; REGULATES ANGIOGENESIS; PROMOTES ANGIOGENESIS; MECHANICAL-PROPERTIES; PROTEIN ADSORPTION;
D O I
10.1186/s12951-020-00755-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Skin is the body's first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.
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页数:21
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