Improved tissue adhesion property of a hydrophobically modified Alaska pollock derived gelatin sheet by UV treatment

被引：6

作者：

Ichimaru, Hiroaki ^{[1
,2
]}

Taguchi, Tetsushi ^{[1
,2
]}

机构：

[1] Univ Tsukuba, Grad Sch Pure & Appl Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan

[2] Natl Inst Mat Sci, Res Ctr Funct Mat, Polymers & Biomat Field, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 172卷

基金：

日本学术振兴会;

关键词：

Tissue adhesion; Hydrophobic interaction; Electrospinning; UV irradiation; Alaska pollock gelatin; STEM-CELLS; NANOFIBERS; BIOCOMPATIBILITY; SEALANTS; STRENGTH;

D O I：

10.1016/j.ijbiomac.2021.01.085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue adhesives have been developed for sealing tissue damaged in surgery. Among these, sheet-type adhesives require a relatively long time to adhere to biological tissue under wet conditions. To address this clinical problem, we fabricated a tissue-adhesive fiber sheet (AdFS) based on decanyl group (C10) modified Alaska pollock-derived gelatin (C10-ApGltn) using electrospinning. Ultraviolet (UV) irradiation of the MIS was performed to increase the affinity between the AdFS and wet biological tissue by introducing hydrophilic functional groups. The UV irradiated MIS (UV-C10-AdFS) strongly adhered to porcine pleura within 2 min under wet conditions and showed higher burst strength compared with the original ApGltn (Org-ApGltn) sheet. Hematoxylin-eosin stained sections revealed that a dense UV-C10-AdFS layer remained on the surface of the porcine pleura even after burst strength measurement. Moreover, UV-C10-AdFS has excellent cytocompatibility and efficiently supports the growth of L929 cells. UV-C10-AdFS is a promising adhesive material for sealing wet biological tissue. (C) 2021 Elsevier B.V. All tights reserved.

引用

页码：580 / 588

页数：9

共 51 条

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