Tat is a multifunctional viral protein that modulates cellular gene expression and functions

被引：81

作者：

Clark, Evan ^{[1
]}

Nava, Brenda ^{[1
]}

Caputi, Massimo ^{[1
]}

机构：

[1] Florida Atlantic Univ, Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 16期

关键词：

HIV-1; Tat; transcription; gene regulation; BLOOD-BRAIN-BARRIER; SIMIAN IMMUNODEFICIENCY VIRUS; INTERFERON-STIMULATED GENES; HIV-1; TAT; T-CELLS; P-TEFB; TRANSCRIPTIONAL ELONGATION; KAPOSIS-SARCOMA; GROWTH-FACTOR; UP-REGULATION;

D O I：

10.18632/oncotarget.15174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human immunodeficiency virus type I (HIV-1) has developed several strategies to condition the host environment to promote viral replication and spread. Viral proteins have evolved to perform multiple functions, aiding in the replication of the viral genome and modulating the cellular response to the infection. Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by altering the immune response and facilitating viral spread to multiple tissues. Studies carried out utilizing biochemical, cellular, and genomic approaches show that the expression and activity of hundreds of genes and multiple molecular networks are modulated by Tat via multiple mechanisms.

引用

页码：27569 / 27581

页数：13

共 130 条

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