Astrocytic Regulation of Neural Circuits Underlying Behaviors

被引：16

作者：

Hwang, Sun-Nyoung ^{[1
]}

Lee, Jae Seung ^{[2
]}

Seo, Kain ^{[2
]}

Lee, Hyosang ^{[1
,2
,3
]}

机构：

[1] Daegu Gyeongbuk Inst Sci & Technol DGIST, Convergence Res Adv Ctr Olfact, Daegu 42988, South Korea

[2] DGIST, Dept Brain & Cognit Sci, Daegu 42988, South Korea

[3] Korea Brain Res Inst KBRI, Daegu 41062, South Korea

来源：

CELLS | 2021年 / 10卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

astrocyte; neural circuit; behavior; GFAP; chemogenetics; optogenetics;

D O I：

10.3390/cells10020296

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels.

引用

页码：1 / 24

页数：27

共 166 条

[21] Activation of Extracellular Signal-Regulated Kinase in the Anterior Cingulate Cortex Contributes to the Induction and Expression of Affective Pain [J].

Cao, Hong ;

Gao, Yong-Jing ;

Ren, Wen-Hua ;

Li, Ting-Ting ;

Duan, Kai-Zheng ;

Cui, Yi-Hui ;

Cao, Xiao-Hua ;

Zhao, Zhi-Qi ;

Ji, Ru-Rong ;

Zhang, Yu-Qiu .

JOURNAL OF NEUROSCIENCE, 2009, 29 (10) :3307-3321

[22] Astrocyte-derived ATP modulates depressive-like behaviors [J].

Cao, Xiong ;

Li, Liang-Ping ;

Wang, Qian ;

Wu, Qiong ;

Hu, Hong-Hai ;

Zhang, Meng ;

Fang, Ying-Ying ;

Zhang, Jie ;

Li, Shu-Ji ;

Xiong, Wen-Chao ;

Yan, Hua-Cheng ;

Gao, Yu-Bo ;

Liu, Ji-Hong ;

Li, Xiao-Wen ;

Sun, Li-Rong ;

Zeng, Yuan-Ning ;

Zhu, Xin-Hong ;

Gao, Tian-Ming .

NATURE MEDICINE, 2013, 19 (06) :773-+

[23] Genetic identification of a neural circuit that suppresses appetite [J].

Carter, Matthew E. ;

Soden, Marta E. ;

Zweifel, Larry S. ;

Palmiter, Richard D. .

NATURE, 2013, 503 (7474) :111-+

[24] Developmental Origins of Astrocyte Heterogeneity: The Final Frontier of CNS Development [J].

Chaboub, Lesley S. ;

Deneen, Benjamin .

DEVELOPMENTAL NEUROSCIENCE, 2012, 34 (05) :379-388

[25] Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence [J].

Chai, Hua ;

Diaz-Castro, Blanca ;

Shigetomi, Eiji ;

Monte, Emma ;

Octeau, J. Christopher ;

Yu, Xinzhu ;

Cohn, Whitaker ;

Rajendran, Pradeep S. ;

Vondriska, Thomas M. ;

Whitelegge, Julian P. ;

Coppola, Giovanni ;

Khakh, Baljit S. .

NEURON, 2017, 95 (03) :531-+

[26] Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model [J].

Chen, Feng-Li ;

Dong, Yu-Lin ;

Zhang, Zhi-Jun ;

Cao, De-Li ;

Xu, Jie ;

Hui, Jie ;

Zhu, Li ;

Gao, Yong-Jing .

BRAIN RESEARCH BULLETIN, 2012, 87 (01) :60-66

[27] Parabrachial Complex: A Hub for Pain and Aversion [J].

Chiang, Michael C. ;

Bowen, Anna ;

Schier, Lindsey A. ;

Tupone, Domenico ;

Uddin, Olivia ;

Heinricher, Mary M. .

JOURNAL OF NEUROSCIENCE, 2019, 39 (42) :8225-8230

[28] Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity [J].

Corkrum, Michelle ;

Covelo, Ana ;

Lines, Justin ;

Bellocchio, Luigi ;

Pisansky, Marc ;

Loke, Kelvin ;

Quintana, Ruth ;

Rothwell, Patrick E. ;

Lujan, Rafael ;

Marsicano, Giovanni ;

Martin, Eduardo D. ;

Thomas, Mark J. ;

Kofuji, Paulo ;

Araque, Alfonso .

NEURON, 2020, 105 (06) :1036-+

[29] CA2+ WAVES IN ASTROCYTES [J].

CORNELLBELL, AH ;

FINKBEINER, SM .

CELL CALCIUM, 1991, 12 (2-3) :185-204

[30] Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography [J].

Croxson, PL ;

Johansen-Berg, H ;

Behrens, TEJ ;

Robson, MD ;

Pinsk, MA ;

Gross, CG ;

Richter, W ;

Richter, MC ;

Kastner, S ;

Rushworth, MFS .

JOURNAL OF NEUROSCIENCE, 2005, 25 (39) :8854-8866

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