Astrocytic Regulation of Neural Circuits Underlying Behaviors

被引：16

作者：

Hwang, Sun-Nyoung ^{[1
]}

Lee, Jae Seung ^{[2
]}

Seo, Kain ^{[2
]}

Lee, Hyosang ^{[1
,2
,3
]}

机构：

[1] Daegu Gyeongbuk Inst Sci & Technol DGIST, Convergence Res Adv Ctr Olfact, Daegu 42988, South Korea

[2] DGIST, Dept Brain & Cognit Sci, Daegu 42988, South Korea

[3] Korea Brain Res Inst KBRI, Daegu 41062, South Korea

来源：

CELLS | 2021年 / 10卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

astrocyte; neural circuit; behavior; GFAP; chemogenetics; optogenetics;

D O I：

10.3390/cells10020296

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels.

引用

页码：1 / 24

页数：27

共 166 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[2] Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement [J].

Adamsky, Adar ;

Kol, Adi ;

Kreisel, Tirzah ;

Doron, Adi ;

Ozeri-Engelhard, Nofar ;

Melcer, Talia ;

Refaeli, Ron ;

Horn, Henrike ;

Regev, Limor ;

Groysman, Maya ;

London, Michael ;

Goshen, Inbal .

CELL, 2018, 174 (01) :59-+

[3] Glia as architects of central nervous system formation and function [J].

Allen, Nicola J. ;

Lyons, David A. .

SCIENCE, 2018, 362 (6411) :181-+

[4] Astrocyte-mediated control of cerebral microcirculation [J].

Anderson, CM ;

Nedergaard, M .

TRENDS IN NEUROSCIENCES, 2003, 26 (07) :340-344

[5] AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training [J].

Aponte, Yexica ;

Atasoy, Deniz ;

Sternson, Scott M. .

NATURE NEUROSCIENCE, 2011, 14 (03) :351-355

[6] Gliotransmitters Travel in Time and Space [J].

Araque, Alfonso ;

Carmignoto, Giorgio ;

Haydon, Philip G. ;

Oliet, Stephane H. R. ;

Robitaille, Richard ;

Volterra, Andrea .

NEURON, 2014, 81 (04) :728-739

[7] Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand [J].

Armbruster, Blaine N. ;

Li, Xiang ;

Pausch, Mark H. ;

Herlitze, Stefan ;

Roth, Bryan L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5163-5168

[8] Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI [J].

Balderston, Nicholas L. ;

Schultz, Douglas H. ;

Hopkins, Lauren ;

Helmstetter, Fred J. .

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2015, 10 (12) :1615-1622

[9] Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors [J].

Banasr, Mounira ;

Duman, Ronald S. .

BIOLOGICAL PSYCHIATRY, 2008, 64 (10) :863-870

[10] Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters [J].

Bang, Juwon ;

Kim, Hak Yeong ;

Lee, Hyosang .

EXPERIMENTAL NEUROBIOLOGY, 2016, 25 (05) :205-221

← 1 2 3 4 5 6 7 8 9 10 →