Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

被引：216

作者：

Milkovic, Lidija ^{[1
]}

Gasparovic, Ana Cipak ^{[1
]}

Cindric, Marina ^{[2
]}

Mouthuy, Pierre-Alexis ^{[3
]}

Zarkovic, Neven ^{[1
]}

机构：

[1] Rudjer Boskovic Inst, Div Mol Med, Lab Oxidat Stress, Bijenicka 54, Zagreb 10000, Croatia

[2] Univ Hosp Ctr Zagreb, Dept Pathol & Cytol, Lab Mol Pathol, Salata 10, Zagreb 10000, Croatia

[3] Univ Oxford, Oxford Musculoskeletal Biomed Res Unit, Natl Inst Hlth Res, Botnar Res Ctr,Nuffield Dept Orthopaed,Rheumatol, Oxford OX3 7LD, England

来源：

CELLS | 2019年 / 8卷 / 08期

关键词：

reactive oxygen species (ROS); redox signaling; cellular processes; physiology; cancer; metabolism; therapy; BRAIN ENERGY-METABOLISM; NF-KAPPA-B; OXIDATIVE STRESS; STEM-CELLS; CANCER; ANTIOXIDANTS; MECHANISMS; ACTIVATION; APOPTOSIS; FERTILIZATION;

D O I：

10.3390/cells8080793

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here.

引用

页数：14

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