Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

被引：81
|
作者：
Seki, Hiroyuki [1 ,2 ]
Tani, Yukako [1 ]
Arita, Makoto [1 ,3 ]
机构：
[1] Univ Tokyo, Dept Hlth Chem, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] Keio Univ, Sch Med, Dept Anesthesiol, Shinjuku Ku, Tokyo 1608582, Japan
[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama, Japan
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2009年 / 89卷 / 3-4期
关键词：
Omega-3; PUFA; Resolvins; Inflammation; Lipidomics; POLYUNSATURATED FATTY-ACIDS; INFLAMMATORY-BOWEL-DISEASE; TRANSGENIC MICE; DOCOSAHEXAENOIC ACID; HUMAN-NEUTROPHILS; LIPOXIN A(4); BIOSYNTHESIS; ASPIRIN; RESOLUTION; PRODUCTS;
D O I：
10.1016/j.prostaglandins.2009.03.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin El. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：126 / 130
页数：5
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