Synthesis of Polysubstituted Pyrroles

被引：8

作者：

Poulard, Celine ^{[1
]}

Cornet, Julien ^{[1
]}

Legoupy, Stephanie ^{[1
]}

Dujardin, Gilles ^{[1
]}

Dhal, Robert ^{[1
]}

Huet, Francois ^{[1
]}

机构：

[1] Univ Maine, Synth Organ Lab, CNRS, UCO2M,UMR 6011, F-72085 Le Mans 9, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 05期

关键词：

Lavendamycin; pyrroles; TosMIC; Michael acceptors; cross metathesis; SULFONYLMETHYL ISOCYANIDES; STREPTOMYCES-LAVENDULAE; TOSYLMETHYL ISOCYANIDE; LAVENDAMYCIN ANALOGS; OLEFIN METATHESIS; DERIVATIVES; CHEMISTRY;

D O I：

10.2174/157017809788681338

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cross coupling metathesis reactions from two ethylenic compounds 4 and 5 easily led to Michael acceptors 6a-b and 7a-b. Reaction of these compounds, or of enone 5', with p-toluenesulfonylmethyl isocyanide (TosMIC) provided the disubstituted pyrroles 9a-c and 10a-b. The analogous reaction of compounds 6a-b and 5', but in presence of Ph3SnCl, provided the trisubstituted pyrroles 11a-c. All of these compounds 9-11 were thus obtained in two steps only.

引用

页码：359 / 361

页数：3

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