Antibiotic lock with vancomycin and urokinase can successfully treat colonized central venous catheters in pediatric cancer patients

被引：27

作者：

De Sio, L ^{[1
]}

Jenkner, A ^{[1
]}

Milano, GM ^{[1
]}

Ilari, I ^{[1
]}

Fidani, P ^{[1
]}

Castellano, A ^{[1
]}

Gareri, R ^{[1
]}

Donfrancesco, A ^{[1
]}

机构：

[1] Osped Pediat Bambino Gesu, IRCCS, Div Pediat Oncol, Rome, Italy

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2004年 / 23卷 / 10期

关键词：

antibiotic lock technique; central venous catheter; Gram-positive bacteremia; vancomycin; urokinase; pediatric cancer patients;

D O I：

10.1097/01.inf.0000141740.82420.e6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used an antibiotic lock technique with vancomycin in combination with urokinase in 10 consecutive eligible children with Gram-positive catheter-related bacteremia persisting after appropriate intravenous antibiotics. Treatment was successful in sterilizing all colonized central venous catheters, avoiding device removal and delay of further chemotherapy. The antibiotic lock technique may represent a safe and effective therapeutic option in patients with selected, uncomplicated catheter-related bacteremias resistant to systemic antimicrobial therapy, particularly when maintaining a venous access is mandatory.

引用

页码：963 / 965

页数：3

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